A0A650CHD3 · A0A650CHD3_SULOH

Function

function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site875-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site915-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site112-1205-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site116orotate (UniProtKB | ChEBI)
Binding site144orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Biological Process'de novo' UMP biosynthetic process
Biological Processpyrimidine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • ORF names
      D1869_08325
      , HNQ62_000065

Organism names

  • Taxonomic identifier
  • Strains
    • TA-1
    • DSM 12421
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfurisphaera

Accessions

  • Primary accession
    A0A650CHD3

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-152Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    195
  • Mass (Da)
    21,714
  • Last updated
    2020-04-22 v1
  • Checksum
    6CF9E1BDD2309C82
MDFIKSLVENKLLLIGNFVLTSGKISPYYLDLRRLSNYYEIFSDTVNKAIDKIKNIDFDMIIGIATGGIPFASFISCRMGKPLGYIRMEKKGYGTDKILEADVSGRKILLVDDVATTGGSLSKAVEIINSEGGRVVASLVIVDREEGAEKKLGEYGVKLISVYKIREILEYLLNSSLISDNDKNNIKEYLVKNIE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACHFY010000001
EMBL· GenBank· DDBJ
MBB5252347.1
EMBL· GenBank· DDBJ
Genomic DNA
CP045484
EMBL· GenBank· DDBJ
QGR17193.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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