A0A650CED7 · A0A650CED7_SULOH
- ProteinS-methyl-5'-thioadenosine phosphorylase
- GenemtnP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids270 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Catalytic activity
- S-methyl-5'-thioadenosine + phosphate = S-methyl-5-thio-alpha-D-ribose 1-phosphate + adenine
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 16 | phosphate (UniProtKB | ChEBI) | |||
Binding site | 58-59 | phosphate (UniProtKB | ChEBI) | |||
Binding site | 91-92 | phosphate (UniProtKB | ChEBI) | |||
Site | 171 | Important for substrate specificity | |||
Binding site | 190 | substrate | |||
Binding site | 191 | phosphate (UniProtKB | ChEBI) | |||
Binding site | 214-216 | substrate | |||
Site | 225 | Important for substrate specificity | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | S-methyl-5-thioadenosine phosphorylase activity | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS-methyl-5'-thioadenosine phosphorylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfurisphaera
Accessions
- Primary accessionA0A650CED7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homohexamer. Dimer of a homotrimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 10-248 | Nucleoside phosphorylase | |||
Sequence similarities
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length270
- Mass (Da)29,994
- Last updated2020-04-22 v1
- ChecksumD3897ACE54DD7557
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACHFY010000002 EMBL· GenBank· DDBJ | MBB5252931.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP045484 EMBL· GenBank· DDBJ | QGR16139.1 EMBL· GenBank· DDBJ | Genomic DNA |