A0A650CED7 · A0A650CED7_SULOH

  • Protein
    S-methyl-5'-thioadenosine phosphorylase
  • Gene
    mtnP
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site16phosphate (UniProtKB | ChEBI)
Binding site58-59phosphate (UniProtKB | ChEBI)
Binding site91-92phosphate (UniProtKB | ChEBI)
Site171Important for substrate specificity
Binding site190substrate
Binding site191phosphate (UniProtKB | ChEBI)
Binding site214-216substrate
Site225Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-methyl-5'-thioadenosine phosphorylase
  • EC number
  • Alternative names
    • 5'-methylthioadenosine phosphorylase
      (MTA phosphorylase
      ; MTAP
      )

Gene names

    • Name
      mtnP
    • ORF names
      D1869_02245
      , HNQ62_000664

Organism names

  • Taxonomic identifier
  • Strains
    • TA-1
    • DSM 12421
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfurisphaera

Accessions

  • Primary accession
    A0A650CED7

Proteomes

Subcellular Location

Interaction

Subunit

Homohexamer. Dimer of a homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-248Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    270
  • Mass (Da)
    29,994
  • Last updated
    2020-04-22 v1
  • Checksum
    D3897ACE54DD7557
MIEPKEKASIGIIGGSGLYDPQILTNVKEIKVYTPYGEPSDNIILGELEGKKVAFLPRHGRGHRIPPHKINYRANIWALKSLGAKWVIAVSAVGSLRLDYKPGDFVVPNQFIDMTKGRTYTFFDGPSVAHVSMADPFCEHLRSIILDSAKDLGITTHDKGTYICIEGPRFSTRAESIVWKEVFKADIIGMTLVPEVNLACEAEMCYSVIGMVTDYDVFADIPVTAEEVTKVMAENTAKVKKLLYEVIRRLPEKPDERKCSCCQALKTALV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACHFY010000002
EMBL· GenBank· DDBJ
MBB5252931.1
EMBL· GenBank· DDBJ
Genomic DNA
CP045484
EMBL· GenBank· DDBJ
QGR16139.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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