A0A650CDT6 · A0A650CDT6_SULOH

  • Protein
    [LysW]-lysine/[LysW]-ornithine hydrolase
  • Gene
    lysK
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 2 Zn2+ or Co2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis.
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site67Zn2+ 1 (UniProtKB | ChEBI)
Active site69
Binding site91Zn2+ 1 (UniProtKB | ChEBI)
Binding site91Zn2+ 2 (UniProtKB | ChEBI)
Active site121Proton acceptor
Binding site122Zn2+ 2 (UniProtKB | ChEBI)
Binding site145Zn2+ 1 (UniProtKB | ChEBI)
Binding site316Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarboxypeptidase activity
Molecular Functioncobalt ion binding
Molecular Functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Molecular Functionzinc ion binding
Biological Processarginine biosynthetic process via ornithine
Biological Processlysine biosynthetic process via aminoadipic acid

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    [LysW]-lysine/[LysW]-ornithine hydrolase
  • EC number

Gene names

    • Name
      lysK
    • ORF names
      D1869_00420
      , HNQ62_001013

Organism names

  • Taxonomic identifier
  • Strains
    • TA-1
    • DSM 12421
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfurisphaera

Accessions

  • Primary accession
    A0A650CDT6

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain157-247Peptidase M20 dimerisation

Sequence similarities

Belongs to the peptidase M20A family. LysK subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    346
  • Mass (Da)
    38,904
  • Last updated
    2020-04-22 v1
  • Checksum
    403FD14F2BD41291
MQLEKELLRRKIKELLLEILSIYTPSGEEERAKDFFEKVSKEFNLNLEISKSKSYFLGKGDILLASHIDTVPGFIQPKIEGEVIYGRGAVDAKGPLIAMLLATYILNEKGYKVQFAALADEEGKSKGARELANSGIRYNYIIVGEPSNTLDVIVEYRGVLHLDILCRGNSQHSSSSKENLIVDLSKKILEIYREPSNYENFSIVPTIIKSGDYINMTPSEGYLHLDIRYSIKNSKDEILALIHNEFKTCDIKIVEDIEPVKVDVNSNIVKAVMRGIIKQGFKPKLARKAGTSDMNILKNIAKEIVTYGPGNSTLEHTNNEKISIDEIFIALTTYINAIEELCLKKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACHFY010000003
EMBL· GenBank· DDBJ
MBB5253271.1
EMBL· GenBank· DDBJ
Genomic DNA
CP045484
EMBL· GenBank· DDBJ
QGR15825.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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