A0A650CDT6 · A0A650CDT6_SULOH
- Protein[LysW]-lysine/[LysW]-ornithine hydrolase
- GenelysK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids346 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
Catalytic activity
- [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine
Cofactor
Co2+ (UniProtKB | Rhea| CHEBI:48828 )
Note: Binds 2 Zn2+ or Co2+ ions per subunit.
Pathway
Amino-acid biosynthesis; L-arginine biosynthesis.
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 67 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 69 | |||||
Sequence: D | ||||||
Binding site | 91 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 91 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 121 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 122 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 145 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 316 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carboxypeptidase activity | |
Molecular Function | cobalt ion binding | |
Molecular Function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | |
Molecular Function | zinc ion binding | |
Biological Process | arginine biosynthetic process via ornithine | |
Biological Process | lysine biosynthetic process via aminoadipic acid |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[LysW]-lysine/[LysW]-ornithine hydrolase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfurisphaera
Accessions
- Primary accessionA0A650CDT6
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 157-247 | Peptidase M20 dimerisation | ||||
Sequence: RGVLHLDILCRGNSQHSSSSKENLIVDLSKKILEIYREPSNYENFSIVPTIIKSGDYINMTPSEGYLHLDIRYSIKNSKDEILALIHNEFK |
Sequence similarities
Belongs to the peptidase M20A family. LysK subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length346
- Mass (Da)38,904
- Last updated2020-04-22 v1
- Checksum403FD14F2BD41291
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACHFY010000003 EMBL· GenBank· DDBJ | MBB5253271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP045484 EMBL· GenBank· DDBJ | QGR15825.1 EMBL· GenBank· DDBJ | Genomic DNA |