A0A640KQ73 · A0A640KQ73_LEITA

Function

function

Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site114-116S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site197-198S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial membrane
Molecular Functionphosphatidyl-N-dimethylethanolamine N-methyltransferase activity
Molecular Functionphosphatidyl-N-methylethanolamine N-methyltransferase activity
Molecular Functionphosphatidylethanolamine N-methyltransferase activity
Biological Processmethylation
Biological Processphosphatidylcholine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylethanolamine N-methyltransferase
  • EC number
  • Short names
    PEAMT
    ; PEMT
  • Alternative names
    • Phospholipid methyltransferase
      (PLMT
      )

Gene names

    • ORF names
      LtaPh_3127200

Organism names

Accessions

  • Primary accession
    A0A640KQ73

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-14Lumenal
Transmembrane12-33Helical
Intramembrane15-35Helical
Topological domain36-47Lumenal
Transmembrane53-71Helical
Transmembrane108-129Helical
Topological domain131-173Lumenal
Transmembrane166-189Helical
Topological domain196-224Cytoplasmic

Keywords

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    224
  • Mass (Da)
    24,304
  • Last updated
    2020-04-22 v1
  • Checksum
    A000FFBAF1D63647
MQSTTMTAASGIHYRSIGIATVAIAGLPTLWNIVARNEYRRHTIEKAVGGKKAGAFLMAAAIFVASGLRDYTFHKAMTQNPSSVFPILSTHFFGPENAGVLRRFMRGFGAALMATGTTLVVSSFLRLGITGTYLGDYFGILMDERVTAFPFSHFDNPMYLGATLNFLAASIAQNNAVGTLLTGLVALVYHVSTKYFENPFTAMIYRKRSEERTATGASASMKTQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BLBS01000047
EMBL· GenBank· DDBJ
GET91235.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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