A0A640KQ73 · A0A640KQ73_LEITA
- ProteinPhosphatidylethanolamine N-methyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids224 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
Catalytic activity
- 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H+ + S-adenosyl-L-homocysteine
Pathway
Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | mitochondrial membrane | |
Molecular Function | phosphatidyl-N-dimethylethanolamine N-methyltransferase activity | |
Molecular Function | phosphatidyl-N-methylethanolamine N-methyltransferase activity | |
Molecular Function | phosphatidylethanolamine N-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | phosphatidylcholine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylethanolamine N-methyltransferase
- EC number
- Short namesPEAMT ; PEMT
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania > lizard Leishmania
Accessions
- Primary accessionA0A640KQ73
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-14 | Lumenal | ||||
Sequence: MQSTTMTAASGIHY | ||||||
Transmembrane | 12-33 | Helical | ||||
Sequence: IHYRSIGIATVAIAGLPTLWNI | ||||||
Intramembrane | 15-35 | Helical | ||||
Sequence: RSIGIATVAIAGLPTLWNIVA | ||||||
Topological domain | 36-47 | Lumenal | ||||
Sequence: RNEYRRHTIEKA | ||||||
Transmembrane | 53-71 | Helical | ||||
Sequence: AGAFLMAAAIFVASGLRDY | ||||||
Transmembrane | 108-129 | Helical | ||||
Sequence: FGAALMATGTTLVVSSFLRLGI | ||||||
Topological domain | 131-173 | Lumenal | ||||
Sequence: GTYLGDYFGILMDERVTAFPFSHFDNPMYLGATLNFLAASIAQ | ||||||
Transmembrane | 166-189 | Helical | ||||
Sequence: FLAASIAQNNAVGTLLTGLVALVY | ||||||
Topological domain | 196-224 | Cytoplasmic | ||||
Sequence: FENPFTAMIYRKRSEERTATGASASMKTQ |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length224
- Mass (Da)24,304
- Last updated2020-04-22 v1
- ChecksumA000FFBAF1D63647