A0A640K9W2 · A0A640K9W2_LEITA

Function

function

Has an integral role during the infection of macrophages in the mammalian host.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.
    EC:3.4.24.36 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

166650100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site330Zn2+ (UniProtKB | ChEBI); catalytic
Active site331
Binding site334Zn2+ (UniProtKB | ChEBI); catalytic
Binding site400Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processcell adhesion
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Leishmanolysin
  • EC number

Gene names

    • ORF names
      LtaPh_1009461

Organism names

Accessions

  • Primary accession
    A0A640K9W2

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region37-57Disordered

Sequence similarities

Belongs to the peptidase M8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    666
  • Mass (Da)
    71,241
  • Last updated
    2020-04-22 v1
  • Checksum
    0CCA87CDA371A819
MLSSPLPLAPLTTLPDAVSAPPLSPLLPLAPPPSLLSPLFTEPPTHPRSPPSSILSLRTHPHTCRAMSVDSSSTHRCRSVAPRPVRLAAAGAAVIVAVGTATAWAHAGAVQHRCIHDSMQARVVQSVAEQRSHPSSVSLLGLPYVTLDAADPAFTTNATTDKQRSVVQTKQWGTLRVAVSTEELTDPACHCAQVGQNVSTHNGRFATCTAEDILTDEKRDILVKHLLPQALQLHTERLKVRQVQGTWKVTGMVGNICGSFKVPQAHIAKGLSNTDFVLYVASVPSEPDVLACATTCQVFSDGRPAVGVINIPAASIAPRYSQWILRATAHEMAHALGFTIFFFQQAAMLKSLPNVRDKPGSVPVITSSTVVAKAREQYGCETLEHLELEDHGGSGSAGSHIKMRNAKDELMAPAAGGGYYTALTMAIFQDLGFYQADFSKAEEMPWGKDAGCAFLSEKCMEKNITKWPSMFCNSTEQRYVCPTNRLALGSCVITHNKTAVPPYFQYFTEKHLSGSSALMDYCPVVVVYRSGSCAQSAAAASFSFNAFNLFSDAARCIDGSFKPKRSNWTIPSYGAMCANVRCKAATRTYSVRVRGSTRYVQCTPGRKVDLSSVSDAFEKGGYITCPPYVEVCQGNVRAAQAAAGHRAPCAAVIALLGAALLAVACA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BLBS01000011
EMBL· GenBank· DDBJ
GET86506.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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