A0A5V6UH73 · A0A5V6UH73_SALTM
- ProteinAnthranilate phosphoribosyltransferase
- GenetrpD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids531 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Catalytic activity
- diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate
Cofactor
Note: Binds 2 magnesium ions per monomer.
Pathway
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 84 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 170 | |||||
Sequence: H | ||||||
Active site | 172 | |||||
Sequence: E | ||||||
Binding site | 278 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 278 | anthranilate 1 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 281-282 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: GD | ||||||
Binding site | 286 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 288-291 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: NIST | ||||||
Binding site | 290 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 306-314 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: KHGNRSVSS | ||||||
Binding site | 309 | anthranilate 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 318 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 364 | anthranilate 2 (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 422 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 423 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 423 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | anthranilate phosphoribosyltransferase activity | |
Molecular Function | lyase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | glutamine metabolic process | |
Biological Process | tryptophan biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAnthranilate phosphoribosyltransferase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionA0A5V6UH73
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-186 | Glutamine amidotransferase | ||||
Sequence: LLLDNIDSFTWNLADQLRTNGHNVVIYRNHIPAQTLIDRLATMKNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLANPLPVARYHSLVGSNVPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGARLLEQT | ||||||
Domain | 201-263 | Glycosyl transferase family 3 N-terminal | ||||
Sequence: QPILEKLYQAQTLTQQESHQLFSAVVRGELKPEQLAAALVSMKIRGEHPNEIAGAATALLENA | ||||||
Domain | 272-521 | Glycosyl transferase family 3 | ||||
Sequence: LFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSDLLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGLRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPIAETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQDQLAGGTPEENRDILTRLLQGKGDAAHEAAVAANVAMLMRLHGQEDLKANAQTVLDVLRNGTAY |
Sequence similarities
Belongs to the anthranilate phosphoribosyltransferase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length531
- Mass (Da)56,918
- Last updated2020-04-22 v1
- Checksum256D2409062CD4C7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LR881463 EMBL· GenBank· DDBJ | CAD5309087.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHDKE010000005 EMBL· GenBank· DDBJ | EBU8556909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHHPX010000004 EMBL· GenBank· DDBJ | EBW1890936.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMJIC010000045 EMBL· GenBank· DDBJ | EDH9460324.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAMGT010000001 EMBL· GenBank· DDBJ | HAC6591232.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAH010000020 EMBL· GenBank· DDBJ | HAC9001022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAN010000001 EMBL· GenBank· DDBJ | HAC9010430.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAP010000001 EMBL· GenBank· DDBJ | HAC9019956.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAO010000002 EMBL· GenBank· DDBJ | HAC9025144.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAR010000004 EMBL· GenBank· DDBJ | HAC9035552.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAT010000001 EMBL· GenBank· DDBJ | HAC9039383.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAS010000001 EMBL· GenBank· DDBJ | HAC9044430.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAZ010000001 EMBL· GenBank· DDBJ | HAC9049101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAU010000001 EMBL· GenBank· DDBJ | HAC9053968.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANAV010000001 EMBL· GenBank· DDBJ | HAC9068563.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANBA010000001 EMBL· GenBank· DDBJ | HAC9078429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANBG010000001 EMBL· GenBank· DDBJ | HAC9107635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANBH010000001 EMBL· GenBank· DDBJ | HAC9117202.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANBL010000001 EMBL· GenBank· DDBJ | HAC9131810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANBT010000098 EMBL· GenBank· DDBJ | HAC9169429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANBW010000001 EMBL· GenBank· DDBJ | HAC9181186.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANBZ010000001 EMBL· GenBank· DDBJ | HAC9195688.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANCC010000001 EMBL· GenBank· DDBJ | HAC9215316.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANDO010000001 EMBL· GenBank· DDBJ | HAC9399018.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANDS010000001 EMBL· GenBank· DDBJ | HAC9418417.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANDY010000001 EMBL· GenBank· DDBJ | HAC9442400.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANEL010000001 EMBL· GenBank· DDBJ | HAC9505448.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANFM010000001 EMBL· GenBank· DDBJ | HAC9640891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANHR010000045 EMBL· GenBank· DDBJ | HAC9915278.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANHU010000064 EMBL· GenBank· DDBJ | HAC9934804.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAANIH010000073 EMBL· GenBank· DDBJ | HAC9990970.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARCM010000032 EMBL· GenBank· DDBJ | HAE1857537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASWB010000001 EMBL· GenBank· DDBJ | HAE7264015.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP060507 EMBL· GenBank· DDBJ | QNL56444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP067091 EMBL· GenBank· DDBJ | QTQ01395.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP067397 EMBL· GenBank· DDBJ | QTQ05911.1 EMBL· GenBank· DDBJ | Genomic DNA |