A0A5S9YBA4 · A0A5S9YBA4_ARATH

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 2 calcium ions per subunit.
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Features

Showing features for site, active site, binding site.

TypeIDPosition(s)Description
Site558Transition state stabilizer
Active site562Proton acceptor
Binding site563Ca2+ 1 (UniProtKB | ChEBI)
Binding site566Ca2+ 1 (UniProtKB | ChEBI)
Binding site568Ca2+ 1 (UniProtKB | ChEBI)
Binding site570Ca2+ 1 (UniProtKB | ChEBI)
Binding site572Ca2+ 1 (UniProtKB | ChEBI)
Binding site584Ca2+ 1 (UniProtKB | ChEBI)
Binding site657substrate
Binding site687Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue
Binding site688Ca2+ 2 (UniProtKB | ChEBI)
Binding site740Ca2+ 2 (UniProtKB | ChEBI)
Binding site742Ca2+ 2 (UniProtKB | ChEBI)
Binding site747Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentmembrane
Cellular Componentvacuole
Molecular Function12-hydroxyheptadecatrienoic acid synthase activity
Molecular Functionheme binding
Molecular Functionhydrolase activity, acting on ester bonds
Molecular Functionlactoperoxidase activity
Molecular Functionmetal ion binding
Molecular Functionprostaglandin-E synthase activity
Biological Processhydrogen peroxide catabolic process
Biological Processprostaglandin biosynthetic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin E synthase 2
  • EC number
  • Alternative names
    • Microsomal prostaglandin E synthase 2

Gene names

    • ORF names
      C24_LOCUS24223

Organism names

  • Taxonomic identifier
  • Strain
    • cv. C24
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    A0A5S9YBA4

Proteomes

Subcellular Location

Membrane
; Single-pass membrane protein
Vacuole

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond531↔610
Disulfide bond564↔569
Disulfide bond616↔812
Disulfide bond694↔726

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain86-162GST N-terminal
Domain521-816Plant heme peroxidase family profile

Sequence similarities

Belongs to the 'GDSL' lipolytic enzyme family.
Belongs to the GST superfamily.
Belongs to the peroxidase family. Ascorbate peroxidase subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    816
  • Mass (Da)
    89,742
  • Last updated
    2020-04-22 v1
  • Checksum
    84A5E08DC4DC0930
MRRVTGLAARTISSSVAINSRLTQSMAITTISSSEPISRRFGGLPEIKTPSFAGGVAGVVFFSAAAVSSLGQEVHAKEMAQKFNPKEVVLYQYEACPFCNKVKAFLDYNKIPYKVVEVNPISKKEIKWSDYKKVPILTVDGEQMVDSSVIIDSLFQKMHPEISKSEDDEETKWRKWVDNHLVHLLSPNIYRNTSEALESFEYITTHGNFSFTERLVAKYAGATAMYFVSKKLKKKYNITDERAALYDAAETWVDALKERPYLGGSKPNLGDLAVFGVLRPIRYLRSGKDMVDNTRIVVEGSRNTLERNTETNATEAKVEGKGTIKLPPNVTIPGIITFGDSIVDSGNNNHLRTALKCNFPPYGKDFPGKIGTGRFSDGRVPSDIVAERLGIAETIPAYLNPKLKNEDLLKGVNFASGGSGYDPLTAKLVALYGLGARRIGVFSAVPVGCVPAARTLRGKLKRRCSEKLNEVARNFNAKISPTLEALGKELPDSRVVLIDVYDTLNDMIENPKNYVSFDVQALSPHYYDHTCPQADHIVTNAVKKAMSNDQTVPAALLRMHFHDCFVRGCDGSVLLDSKGKNKAEKDGPPNISLHAFYVIDNAKKALEEQCPGIVSCADILSLAARDAVALSGGPTWAVPKGRKDGRISKAIETRQLPAPTFNISQLRQNFGQRGLSMHDLVALSGGHTLGFAHCSSFQNRLHKFNTQKEVDPTLNPSFAARLEGVCPAHNTVKNAGSNMDGTVTSFDNIYYKMLIQGKSLFSSDESLLAVPSTKKLVAKYANSNEEFERAFVKSMIKMSSISGNGNEVRLNCRRVR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CACSHJ010000096
EMBL· GenBank· DDBJ
CAA0406931.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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