A0A5S3QFR2 · A0A5S3QFR2_9BACI

Function

function

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FMNH2 (UniProtKB | Rhea| CHEBI:57618 )

Note: Reduced FMN (FMNH2).

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site39NADP+ (UniProtKB | ChEBI)
Binding site45NADP+ (UniProtKB | ChEBI)
Binding site130-132FMN (UniProtKB | ChEBI)
Binding site251-252FMN (UniProtKB | ChEBI)
Binding site296FMN (UniProtKB | ChEBI)
Binding site311-315FMN (UniProtKB | ChEBI)
Binding site337FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionchorismate synthase activity
Molecular FunctionFMN binding
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chorismate synthase
  • EC number
  • Short names
    CS
  • Alternative names
    • 5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

    • Name
      aroC
    • ORF names
      FFL34_00060

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NKC220-2
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Lentibacillus

Accessions

  • Primary accession
    A0A5S3QFR2

Proteomes

Subcellular Location

Interaction

Subunit

Homotetramer.

Family & Domains

Sequence similarities

Belongs to the chorismate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    388
  • Mass (Da)
    42,934
  • Last updated
    2020-02-26 v1
  • MD5 Checksum
    FBF92951492F2C06028B5E57D1C4ED39
MRYLTAGESHGKQLTTIIEGLPANMPLLQEDINQSLIRRQQGHGRGKRMQIEKDMADITSGVRHGYTLGSPISLVIHNDDFKHWIDIMGEDPIETNKKLRRTVSRPRPGHADLNGALKYGHRDMRNVLERSSARETAARVAAGAVAKTLLNHLGITVSGYVKEIAGITAKENSSLSIADRQRISEESPVRTLDKDVEQQMMDAIDQAKKDGDSIGGVIEVYVEGMPAGIGSYVHYDRKLDGRIAGSVMSINAFKGVEFGLGFEAARKNGSQVHDEIAWDEEDGYYRKTNRLGGFEGGMTTGMPLVIKGVMKPIPTLYKPLQSVDIETKEPFNASIERSDSCAVPAASVVMEHVVAFELAKAITEQFPHDQFPKLQQAIDDYREEIRCF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VCIA01000001
EMBL· GenBank· DDBJ
TMN20678.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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