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A0A5R9CUC2 · A0A5R9CUC2_9LACO

Function

function

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site12-15NADP+ (UniProtKB | ChEBI)
Binding site100phosphate (UniProtKB | ChEBI)
Active site129Acyl-thioester intermediate
Binding site156substrate
Binding site159-160NADP+ (UniProtKB | ChEBI)
Binding site247substrate
Active site254Proton acceptor
Binding site328NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionaspartate-semialdehyde dehydrogenase activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionprotein dimerization activity
Biological Process'de novo' L-methionine biosynthetic process
Biological Processdiaminopimelate biosynthetic process
Biological Processisoleucine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate-semialdehyde dehydrogenase
  • EC number
  • Short names
    ASA dehydrogenase
    ; ASADH
  • Alternative names
    • Aspartate-beta-semialdehyde dehydrogenase

Gene names

    • Name
      asd
    • ORF names
      FEZ41_08940

Organism names

Accessions

  • Primary accession
    A0A5R9CUC2

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-120Semialdehyde dehydrogenase NAD-binding

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    362
  • Mass (Da)
    40,036
  • Last updated
    2020-02-26 v1
  • MD5 Checksum
    C06B389BDF1E7FADCD235C37AAA8B6B8
MREFNVAILGATGAVGTRLISQLEQSTIPVKSIKLLASAHSAGKTLQFKGQDVTVEEAKPASFEGVDLVLASAGGSVSKKFLPEAVKRGAVCVDNTSAFRMEPEVPLVIPEVNEKALYNHRGIISNPNCSTIQMVVCLDPIYRKFGLKQVIVSTYQAVSGAGQSALNELMEESQQVLNGEKTDPKILPTKGDKKHYQQAFNLLPQIDVFEQDGYYTHEEWKMIHETKKIMLDDMDAKDIKVTATCVRVPIRIAHGETVYFEVADDKATTDQIKQTLADAQGVVLQDDTAHQVYPQPIEAEGKRETFVGRVRPDYENDGSYHMWVVSDNLLKGAAWNTVEIAERLVADDLVRVPDNPYLGFEN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VBSX01000020
EMBL· GenBank· DDBJ
TLQ18592.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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