A0A5Q0SIZ3 · A0A5Q0SIZ3_9CREN
- ProteinOrotidine 5'-phosphate decarboxylase
- GenepyrF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids222 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalytic activity
- orotidine 5'-phosphate + H+ = UMP + CO2
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11 | substrate | |||
Binding site | 30 | substrate | |||
Active site | 59 | For OMPdecase activity | |||
Binding site | 59-68 | substrate | |||
Active site | 61 | For OMPdecase activity | |||
Active site | 61 | Proton donor | |||
Active site | 64 | For OMPdecase activity | |||
Binding site | 115 | substrate | |||
Binding site | 164-174 | substrate | |||
Binding site | 187 | substrate | |||
Binding site | 188 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotidine 5'-phosphate decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfolobus
Accessions
- Primary accessionA0A5Q0SIZ3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length222
- Mass (Da)24,783
- Last updated2020-02-26 v1
- ChecksumD651E21279C71000
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP045687 EMBL· GenBank· DDBJ | QGA54634.1 EMBL· GenBank· DDBJ | Genomic DNA |