A0A5Q0SIZ3 · A0A5Q0SIZ3_9CREN

  • Protein
    Orotidine 5'-phosphate decarboxylase
  • Gene
    pyrF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Features

Showing features for binding site, active site.

122220406080100120140160180200220
Type
IDPosition(s)Description
Binding site11substrate
Binding site30substrate
Active site59For OMPdecase activity
Binding site59-68substrate
Active site61For OMPdecase activity
Active site61Proton donor
Active site64For OMPdecase activity
Binding site115substrate
Binding site164-174substrate
Binding site187substrate
Binding site188substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotidine 5'-phosphate decarboxylase
  • EC number
  • Alternative names
    • OMP decarboxylase
      (OMPDCase
      ; OMPdecase
      )

Gene names

    • Name
      pyrF
    • ORF names
      GFS03_08645

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • E5-1-F
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfolobus

Accessions

  • Primary accession
    A0A5Q0SIZ3

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-203Orotidine 5'-phosphate decarboxylase

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    222
  • Mass (Da)
    24,783
  • Last updated
    2020-02-26 v1
  • Checksum
    D651E21279C71000
MLKSKIILAMDKPLSYQTLKEMENEIYGIKVGLPLVLDLGVHKTRELLNDLNVEEIIVDFKLADIGYIMKSIVEKLSFANSFIAHSFVGVKGALDELKKYLDTNSKNLYLVAVMSHEGWSTLFTDYIKNVIREISPKGIVVGGTKLDSITQYRKEFTKITIISPGMGSQGGIYGDAICAGADYEIIGRSIYNADDPFTTIKTINKIIEEKVMNCKGAIFREK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP045687
EMBL· GenBank· DDBJ
QGA54634.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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