A0A5Q0GQF9 · A0A5Q0GQF9_SACSY

Function

function

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

GO annotations

AspectTerm
Molecular Functiondihydropteroate synthase activity
Molecular Functionmetal ion binding
Biological Processfolic acid biosynthetic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydropteroate synthase
  • EC number
  • Short names
    DHPS
  • Alternative names
    • Dihydropteroate pyrophosphorylase

Gene names

    • Name
      folP
    • ORF names
      EKG83_01655

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 51364 / DSM 43886 / JCM 6844 / KCTC 9398 / NBRC 14523 / NRRL B-16468 / INA 2240
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Saccharothrix

Accessions

  • Primary accession
    A0A5Q0GQF9

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-262Pterin-binding

Sequence similarities

Belongs to the DHPS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    272
  • Mass (Da)
    28,484
  • Last updated
    2020-04-22 v1
  • Checksum
    E65C7090D3220073
MTVSRPAHCVVVGVLNVTPDSFSDGGRYLGLDDAVAHGVALHRQGADLVDVGGESTRPGAERVAPDVEAERVAPVIRALVARGVPVSVDTTRARVAEAALEAGASIVNDVSGGLADPDMMRVVAAARVPYVLMHWRGHSRGMDRLAVYDDVVKDVRDELCRQVDAALAAGVAEDDVILDPGLGFAKDADHNWQLLNRLDALVSLGFPVLVGASRKRFLGALLGGRVPDGREDATAAVSALAAFNGAWGVRVHDVARSLDAVAVARAWRAGRG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP034550
EMBL· GenBank· DDBJ
QFZ16336.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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