A0A5Q0GQF9 · A0A5Q0GQF9_SACSY
- ProteinDihydropteroate synthase
- GenefolP
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids272 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Catalytic activity
- (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dihydropteroate synthase activity | |
Molecular Function | metal ion binding | |
Biological Process | folic acid biosynthetic process | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydropteroate synthase
- EC number
- Short namesDHPS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Saccharothrix
Accessions
- Primary accessionA0A5Q0GQF9
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-262 | Pterin-binding | ||||
Sequence: CVVVGVLNVTPDSFSDGGRYLGLDDAVAHGVALHRQGADLVDVGGESTRPGAERVAPDVEAERVAPVIRALVARGVPVSVDTTRARVAEAALEAGASIVNDVSGGLADPDMMRVVAAARVPYVLMHWRGHSRGMDRLAVYDDVVKDVRDELCRQVDAALAAGVAEDDVILDPGLGFAKDADHNWQLLNRLDALVSLGFPVLVGASRKRFLGALLGGRVPDGREDATAAVSALAAFNGAWGVRVHDVARSLDAVA |
Sequence similarities
Belongs to the DHPS family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length272
- Mass (Da)28,484
- Last updated2020-04-22 v1
- ChecksumE65C7090D3220073
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP034550 EMBL· GenBank· DDBJ | QFZ16336.1 EMBL· GenBank· DDBJ | Genomic DNA |