A0A5P9QC24 · A0A5P9QC24_9MICO

Function

function

Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site2-9NADP+ (UniProtKB | ChEBI)
Binding site96NADPH (UniProtKB | ChEBI)
Binding site181L-homoserine (UniProtKB | ChEBI)
Active site196Proton donor

GO annotations

AspectTerm
Molecular Functionhomoserine dehydrogenase activity
Molecular FunctionNADP binding
Biological Processisoleucine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homoserine dehydrogenase
  • EC number

Gene names

    • ORF names
      KDY119_02518

Organism names

Accessions

  • Primary accession
    A0A5P9QC24

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain340-425ACT

Sequence similarities

Belongs to the homoserine dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    425
  • Mass (Da)
    44,109
  • Last updated
    2020-04-22 v1
  • Checksum
    5D56B7FD8300FC0C
MLGCGVVGTEVVRLLTQQADDLAARVGAPLELVGVAVRNVDAPRDPVVDRALLTADADELVTRADIVVELMGGEEPARNLLLRAIEHGASVVTANKALLAQDGPTLYRAADEAGVDVYYEAAVAGAIPIVRPIRESLTGDKIRRVLGIVNGTTNYVLDRMATDGLELEDAVKEAQGLGYAEADPTADVEGYDAAAKAAILASLAFHTRVHLDDVYREGITSVTASDVAWAARTGHAVKLLAIAEATDDGVSVRVHPALVPLDHPLAGVRGAFNAVFVEAEAAGELMFYGRGAGGAPTASAVLGDVVSAARHRVLGGKSPEESTYADLPLLPHASALTRYQVRLVVDDRPGVLAQVASTFAGQGVSIESVRQVPDGDRADVGTGGSAELLLTTHVAPEAALASTTRAARDLAPVREVTSVLRVEGV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP045529
EMBL· GenBank· DDBJ
QFU98993.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp