A0A5P9QBT1 · A0A5P9QBT1_9MICO

Function

function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site78substrate
Binding site98FMN (UniProtKB | ChEBI)
Binding site123-127substrate
Binding site156FMN (UniProtKB | ChEBI)
Binding site189FMN (UniProtKB | ChEBI)
Binding site189substrate
Active site192Nucleophile
Binding site194substrate
Binding site235FMN (UniProtKB | ChEBI)
Binding site263FMN (UniProtKB | ChEBI)
Binding site264-265substrate
Binding site278FMN (UniProtKB | ChEBI)
Binding site307FMN (UniProtKB | ChEBI)
Binding site328-329FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functiondihydroorotate dehydrogenase (quinone) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (quinone)
  • EC number
  • Alternative names
    • DHOdehase
      (DHOD
      ; DHODase
      )
    • Dihydroorotate oxidase

Gene names

    • Name
      pyrD
    • ORF names
      KDY119_02106

Organism names

Accessions

  • Primary accession
    A0A5P9QBT1

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain59-347Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    356
  • Mass (Da)
    37,221
  • Last updated
    2020-04-22 v1
  • Checksum
    BEC1B3DA9717BA97
MKVYAALFQGFFRHLDPEQAHHLAFSVIRAVGVVPGVRTVLRRTLAPFAESTTRGPGSVQALGRSFPAPLGLAGGFDKDALAVRGLATIGFAFVEIGTVTAHAQPGNEKPRLFRVLDQRAIRNRMGFNNRSAAAAAERLKRLRRTSGGRAVVVGANIGKTKVTPSADAAADYATSAGLLAPHADYLVVNVSSPNTPGLRDLQSVESLRPILVAVREAADTATTGSGGPRVPLLVKIAPDLVDDDVDAVADLVLELGLDGVVAVNTTIAHDLGPGGLSGPPLLPRGLDVVRRLRERLGAGPVIIGVGGITTVDDARAYLEAGADLLQGYTAFIYEGPFWASRINRALTTATPSEPGQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP045529
EMBL· GenBank· DDBJ
QFU98590.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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