A0A5P9Q920 · A0A5P9Q920_9MICO

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site23-28NAD+ (UniProtKB | ChEBI)
Binding site47NADP+ (UniProtKB | ChEBI)
Binding site92-94NAD+ (UniProtKB | ChEBI)
Binding site123-126NAD+ (UniProtKB | ChEBI)
Active site153Proton donor/acceptor
Binding site154(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site157Proton donor
Binding site163-164(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • ORF names
      KDY119_01437

Organism names

Accessions

  • Primary accession
    A0A5P9Q920

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-126Dihydrodipicolinate reductase N-terminal
Domain130-264Dihydrodipicolinate reductase C-terminal

Sequence similarities

Belongs to the DapB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    267
  • Mass (Da)
    27,855
  • Last updated
    2020-04-22 v1
  • Checksum
    34CDB145DB17B35D
MTDHVTDEGTPATYSPLRVAVLGAEGRMGRTTCDAVEAAAGLELVARVTRGDDVAQALADSGADVAVDFTRPDVTEENVHAALDAGVHVVVGTTGWTAERQGRVREHLARRAAEGLDLGVIVAPNFGLSAVLAMTFAAKAARYFESVEVIELHHPDKLDAPSGTATHTARAVAAARAAAGVAPSPDATESGFGARGADVDGVRVHAVRLRGLVAHEEILLGNVGEQLVIRQDSFDRVSFMPGVVLAVREVGRRPGLTVGLEHVLDLD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP045529
EMBL· GenBank· DDBJ
QFU97931.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp