A0A5P9K539 · A0A5P9K539_9NIDO

  • Protein
    Replicase polyprotein 1ab
  • Gene
    ORF1AB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

Catalytic activity

Features

Showing features for active site.

154395001,0001,5002,0002,5003,0003,5004,0004,5005,000
TypeIDPosition(s)Description
Active site4556
Active site4558
Active site4659
Active site4732
Active site4737
Active site5045
Active site5062
Active site5096

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Function3'-5'-RNA exonuclease activity
Molecular FunctionATP binding
Molecular Functioncysteine-type peptidase activity
Molecular Functionendonuclease activity
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription
Biological Processmethylation
Biological Processproteolysis
Biological Processviral RNA genome replication
Biological Processviral translational frameshifting

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Replicase polyprotein 1ab
  • Alternative names
    • ORF1ab polyprotein

Gene names

    • Name
      ORF1AB

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • L14
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Tornidovirineae > Tobaniviridae > Serpentovirinae

Accessions

  • Primary accession
    A0A5P9K539

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1317-1341Helical
Transmembrane1382-1401Helical
Transmembrane1504-1523Helical
Transmembrane1802-1820Helical
Transmembrane1964-1984Helical
Transmembrane1996-2029Helical
Transmembrane2035-2068Helical
Transmembrane2444-2463Helical
Transmembrane2496-2514Helical
Transmembrane2571-2598Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-61Basic and acidic residues
Region1-88Disordered
Compositional bias68-88Polar residues
Compositional bias130-157Basic and acidic residues
Region130-191Disordered
Compositional bias158-186Polar residues
Region204-247Disordered
Region300-330Disordered
Compositional bias837-853Polar residues
Region837-890Disordered
Compositional bias859-890Polar residues
Domain3145-3375NiRAN
Domain3673-3825RdRp catalytic
Domain3988-4072CV ZBD
Domain4538-4753ExoN
Domain5017-5151NendoU
Domain5167-5439Nidovirus-type SAM-dependent 2'-O-MTase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    5,439
  • Mass (Da)
    617,066
  • Last updated
    2020-02-26 v1
  • Checksum
    6D96BDABD8DDFD5A

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias1-61Basic and acidic residues
Compositional bias68-88Polar residues
Compositional bias130-157Basic and acidic residues
Compositional bias158-186Polar residues
Compositional bias837-853Polar residues
Compositional bias859-890Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN161571
EMBL· GenBank· DDBJ
QFU19796.1
EMBL· GenBank· DDBJ
Genomic RNA

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