A0A5P9K539 · A0A5P9K539_9NIDO
- ProteinReplicase polyprotein 1ab
- GeneORF1AB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids5439 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 4556 | |||||
Sequence: D | ||||||
Active site | 4558 | |||||
Sequence: E | ||||||
Active site | 4659 | |||||
Sequence: D | ||||||
Active site | 4732 | |||||
Sequence: H | ||||||
Active site | 4737 | |||||
Sequence: D | ||||||
Active site | 5045 | |||||
Sequence: H | ||||||
Active site | 5062 | |||||
Sequence: H | ||||||
Active site | 5096 | |||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | 3'-5'-RNA exonuclease activity | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type peptidase activity | |
Molecular Function | endonuclease activity | |
Molecular Function | mRNA (nucleoside-2'-O-)-methyltransferase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA-templated transcription | |
Biological Process | methylation | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication | |
Biological Process | viral translational frameshifting |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameReplicase polyprotein 1ab
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Tornidovirineae > Tobaniviridae > Serpentovirinae
Accessions
- Primary accessionA0A5P9K539
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1317-1341 | Helical | ||||
Sequence: FLLFLLQPGFFTFALSLMIMAYFLF | ||||||
Transmembrane | 1382-1401 | Helical | ||||
Sequence: YILATANAVICLYLFLYAYW | ||||||
Transmembrane | 1504-1523 | Helical | ||||
Sequence: SVHLVCYNILMTVFIVYLSF | ||||||
Transmembrane | 1802-1820 | Helical | ||||
Sequence: NIFIVLAVLLAIALTRVAY | ||||||
Transmembrane | 1964-1984 | Helical | ||||
Sequence: AFIWITSSVVLCFVFSIFCYI | ||||||
Transmembrane | 1996-2029 | Helical | ||||
Sequence: SVFILMTVHAITVVLYLFVPGLAFVFVIALFFFP | ||||||
Transmembrane | 2035-2068 | Helical | ||||
Sequence: IGTYSFVVCAMFFGLNLVILFGLYTIVFLAIFWF | ||||||
Transmembrane | 2444-2463 | Helical | ||||
Sequence: IIVHCTLSNMLSFCMTLTYF | ||||||
Transmembrane | 2496-2514 | Helical | ||||
Sequence: VVFLLTTGAYFVNMLELFM | ||||||
Transmembrane | 2571-2598 | Helical | ||||
Sequence: CVIFTIIYWTLVYCFGVVNFYTIAVFVF |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-61 | Basic and acidic residues | ||||
Sequence: FQQKEEPQQVKPQEKPQEVKPQEKFQQKEEPQQVKPQEKPQELKPQEKLQQKEKPQEVKLQ | ||||||
Region | 1-88 | Disordered | ||||
Sequence: FQQKEEPQQVKPQEKPQEVKPQEKFQQKEEPQQVKPQEKPQELKPQEKLQQKEKPQEVKLQENPWDIKPLEQAQSQAIATQQLSNHTN | ||||||
Compositional bias | 68-88 | Polar residues | ||||
Sequence: KPLEQAQSQAIATQQLSNHTN | ||||||
Compositional bias | 130-157 | Basic and acidic residues | ||||
Sequence: KTKLEKLNSKKSELEKQLNGKSKSSKSP | ||||||
Region | 130-191 | Disordered | ||||
Sequence: KTKLEKLNSKKSELEKQLNGKSKSSKSPKKADQQATSNKPQQYEQVQQKQLDDIPNVNSGMT | ||||||
Compositional bias | 158-186 | Polar residues | ||||
Sequence: KKADQQATSNKPQQYEQVQQKQLDDIPNV | ||||||
Region | 204-247 | Disordered | ||||
Sequence: TTSPASSRASSSSGPPAATANEQPTTAKPSHEHATVATTTSKPA | ||||||
Region | 300-330 | Disordered | ||||
Sequence: VDSQGTSSSSESSSIPSSQPHQEVQATSQVS | ||||||
Compositional bias | 837-853 | Polar residues | ||||
Sequence: SSTSTKTTATTRSSLVK | ||||||
Region | 837-890 | Disordered | ||||
Sequence: SSTSTKTTATTRSSLVKGNRPAGRPSSVSSMNDSTTSNTTATASSEQAISNQVK | ||||||
Compositional bias | 859-890 | Polar residues | ||||
Sequence: GRPSSVSSMNDSTTSNTTATASSEQAISNQVK | ||||||
Domain | 3145-3375 | NiRAN | ||||
Sequence: VLKQVSDILQQPELYRTVQDDNCQDEQGRWVNVCQLDCGIKRLNKCRTTSIQINNRNHMLKTGTEEDLRHEYNQYIALKDLIAMPEHKLIQLENGSYILIRGPVTEKSLGDLVYSHLHNQTEDAVEIPDKGKPEASEQLANELARQLEPAFDNLDKLRDWCYKYDVQLPITLDNIDLDGQLYDFGDMGTSSHNIDIALGDLMRLWSLTNRAAPKVVKKWFPVKYNLHECGW | ||||||
Domain | 3673-3825 | RdRp catalytic | ||||
Sequence: WKIFGSDYTKCDRSFPLVFRGMAAALLFDLGGWDPHSYHFINEAHAFMFDMVHLDGKIVYKPGGTSSGDATTAFANTLYNHGVHLLVQLQTLVTQPVHNNHLALKTAAVKGFQTGDFTDYDQMLDVYNKKHYKFNFLSDDSFILTNIHDATLP | ||||||
Domain | 3988-4072 | CV ZBD | ||||
Sequence: VQQQCYTCHNPTVSTCIDCPVAYPLCCYCACTHYHETGHKVTHLPVCSHPGCGVSDPEQMNFSLHNSQFTIRCNEHNTEFSIKVY | ||||||
Domain | 4538-4753 | ExoN | ||||
Sequence: TPVTIEQVAANIEASAVCDIEFYHTRHPTRKYPNFLGLGEINCMTSRAVTTFLRPHYNRDGDYLAVTDDYICVSKEWRYMLRHLPSYTDSDMRRNHFLHFLNSTTNLTAHPLIFVLFNGSNDLDALAEITTPAATCHCGKPARFTTNTDEDVCQVHCEGNFLVAVAGGTYYNIRSSSNLTSTHGIVCGKYHGAAHSANNDVVMTACLLDDMLKQHT | ||||||
Domain | 5017-5151 | NendoU | ||||
Sequence: MEQSLFSTGRLATCDHWLFPSEESTECAHIEIGDYNNSSLKIGGMHMFPKAFENVRLNNIEQEASTPLWHANITAKQGTKLHNSLTDVEITRFISCVKDKLTTNTISTRTSIRIDHQNVPIMIWATAGKIDTAYL | ||||||
Domain | 5167-5439 | Nidovirus-type SAM-dependent 2'-O-MTase | ||||
Sequence: SQSYVQYQPVVRAYDTATLLNSNIAHFEVMRNRLDQAVNITKYVQLCNYMNDNIKIPPKATVLHLGAATGPEHDHIPVGGVVLNHFFQNSDVYHHDVRXINDCNGRFKVGLPSQKVDLIISDIWSYNEDTDGEWISNHELLINYVNAHLCLGGSIIWKTTRRSNLSYINYIASHFGQVDYVTTRGNASSSEMFVVFKYFKQQIQQPQAHNRDSWQILHHLFAYRHQYRIYTRQDPLNCDTICKPRSVYRVPKFFEGRIEKSSWASGNFIQQNS |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length5,439
- Mass (Da)617,066
- Last updated2020-02-26 v1
- Checksum6D96BDABD8DDFD5A
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: F | ||||||
Compositional bias | 1-61 | Basic and acidic residues | ||||
Sequence: FQQKEEPQQVKPQEKPQEVKPQEKFQQKEEPQQVKPQEKPQELKPQEKLQQKEKPQEVKLQ | ||||||
Compositional bias | 68-88 | Polar residues | ||||
Sequence: KPLEQAQSQAIATQQLSNHTN | ||||||
Compositional bias | 130-157 | Basic and acidic residues | ||||
Sequence: KTKLEKLNSKKSELEKQLNGKSKSSKSP | ||||||
Compositional bias | 158-186 | Polar residues | ||||
Sequence: KKADQQATSNKPQQYEQVQQKQLDDIPNV | ||||||
Compositional bias | 837-853 | Polar residues | ||||
Sequence: SSTSTKTTATTRSSLVK | ||||||
Compositional bias | 859-890 | Polar residues | ||||
Sequence: GRPSSVSSMNDSTTSNTTATASSEQAISNQVK |
Keywords
- Coding sequence diversity