A0A5P8PEF3 · A0A5P8PEF3_MYTCH

Function

function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleosome
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionprotein heterodimerization activity
Molecular Functionstructural constituent of chromatin
Biological Processnucleosome assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Histone H4

Gene names

    • Name
      H4

Organism names

  • Taxonomic identifier
  • Strains
    • Calbuco2
    • Castro5
    • Mch23
    • Mch3
    • Mch41
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Pteriomorphia > Mytilida > Mytiloidea > Mytilidae > Mytilinae > Mytilus

Accessions

  • Primary accession
    A0A5P8PEF3

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-20Disordered
Domain28-93TATA box binding protein associated factor (TAF) histone-like fold

Sequence similarities

Belongs to the histone H4 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    103
  • Mass (Da)
    11,367
  • Last updated
    2020-02-26 v1
  • Checksum
    A9E5DFD3F8B97598
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN546757
EMBL· GenBank· DDBJ
QFR55038.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546758
EMBL· GenBank· DDBJ
QFR55039.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546759
EMBL· GenBank· DDBJ
QFR55040.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546760
EMBL· GenBank· DDBJ
QFR55041.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546761
EMBL· GenBank· DDBJ
QFR55042.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546762
EMBL· GenBank· DDBJ
QFR55043.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546763
EMBL· GenBank· DDBJ
QFR55044.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546764
EMBL· GenBank· DDBJ
QFR55045.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546765
EMBL· GenBank· DDBJ
QFR55046.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546766
EMBL· GenBank· DDBJ
QFR55047.1
EMBL· GenBank· DDBJ
Genomic DNA
MN546768
EMBL· GenBank· DDBJ
QFR55049.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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