Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A5P1RHA8 · A0A5P1RHA8_9GAMM

  • Protein
    Carbamoyltransferase HypF
  • Gene
    hypF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.

Catalytic activity

Pathway

Protein modification; [NiFe] hydrogenase maturation.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site23
Active site41

GO annotations

AspectTerm
Molecular Functionacylphosphatase activity
Molecular Functioncarboxyl- or carbamoyltransferase activity
Molecular Functiondouble-stranded RNA binding
Molecular Functionligase activity
Molecular Functionzinc ion binding
Biological Processprotein carbamoylation
Biological Processprotein maturation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbamoyltransferase HypF
  • EC number

Gene names

    • Name
      hypF
    • ORF names
      F0U83_10340

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM17730
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Oceanospirillaceae > Neptunomonas

Accessions

  • Primary accession
    A0A5P1RHA8

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-95Acylphosphatase-like
Domain205-396YrdC-like

Sequence similarities

Belongs to the carbamoyltransferase HypF family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    772
  • Mass (Da)
    86,034
  • Last updated
    2020-04-22 v1
  • MD5 Checksum
    73AE19FB99F82793E64E08F23EF3A3E4
MRQVIRKGYRLTVTGLVQGVGFRPFVWHLARQLKLMGQVWNDAAGVTVELVASSQQRDQFIKALTTALPPLARIEHLSCMDAELVINSPDFQIIKSRNGDPLTGCVPDAATCPACISELKDPSNRRYRYPFINCTHCGPRLSILRGIPYDRYQTSMAEFRLCEDCQEEYDNPADRRFHAQPNACAACGPRLWVCDGESREINPVSDPFQLITEQIRQGNIIAIKGIGGFHLVCDATSKEALQRLRERKQRPDKPFALMFRDCESVQRYACLDSDVRQLLQSASAPIVLLASKYQLPTEVAPGQSRLGCMLPHSPVHHLLLESFESPLVMTSANRSGSPQVIDNDEVVSQLQGIADYYVLHDREIVNRVDDSVVAINSHSEGSNNYPKMQVIRRARGYAPAPIKLPPGFERAPDLLALGGELKNTICLIKGGQAIVSQHLGDLEDVRTYDEYLNTIERYQCLYALKPFCLVADNHPEYLSSKYAKASGKRVEWVQHHHAHLSSCLAEHQWPLEGEDLLGLALDGLGLGDDGTLWGGEIFQFNYRQYTRVAYFDPVPLVGGVQAILEPWRCLVAQLHHYGLLDEALPQLPWLDDKPIPVIRSMLKKQLNSPMSSSAGRLFDAVAALLDLSRDRITYEGQAAIELESLAEKVLSVDRTYPMDWRYDGEMRILCWDRLWSAMLDDLSRDTDPALIACAFHHSLAHVLANLLNDLSQATSITTVVLSGGVAQNRLLCRLLAEKLASFGLALLTHKQLPANDGGLSYGQAVVAAARQL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP043869
EMBL· GenBank· DDBJ
QEQ98406.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help