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A0A5P1RF91 · A0A5P1RF91_9GAMM

  • Protein
    Penicillin-binding protein 1B
  • Gene
    mrcB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site195Proton donor; for transglycosylase activity
Active site475Acyl-ester intermediate; for transpeptidase activity

GO annotations

AspectTerm
Cellular Componentpeptidoglycan-based cell wall
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1B
  • Short names
    PBP-1b
    ; PBP1b
  • Alternative names
    • Murein polymerase

Gene names

    • Name
      mrcB
    • ORF names
      F0U83_15115

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM17730
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Oceanospirillaceae > Neptunomonas

Accessions

  • Primary accession
    A0A5P1RF91

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain76-159Bifunctional transglycosylase second
Domain170-340Glycosyl transferase family 51
Domain437-675Penicillin-binding protein transpeptidase

Sequence similarities

In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    784
  • Mass (Da)
    87,685
  • Last updated
    2020-04-22 v1
  • MD5 Checksum
    358115E99798CD784FA38EF88756A3CB
MAKKRTPAKKTSSRAKKAPASRSIWRKLLSLLFKLSLVAFVLGGIGMIYLDAQIREQFEGKRWALPAKVFARPLELYPGAPFSITDLKLELKGLGYQQTTHASKPGQAAFSKSTAHIYTRGFDFPDGRESAQRLILDFSGNTLSRIKSAQGQTLHLARLEPVLIGGIYPQNNEDRDLIRLEDAPVGLKDALIAIEDRSYYEHFGISLKGIARAMWINLQAGRFVQGGSTLTQQLIKNFYLTSERTLARKLMEIPMAVLLDFHYSKEEILEAYLNEVYLGQEGSRAIHGFGLAAQYYFALPIQELQLHQVALLAGLVKGPSYYDPRRNPERAKKRRDLVLSVLRDEGTISESLYQDTIKMPLGVVKQKSLLKGAYPAYLDIVKRQLRESYRDEDLRTEGLRVFTSLNPIVQAKAEAALTKTISSLEKRYGKRLSELEGSMVVTDPQTGEVLSIIGGRSTRYQGFNRALDAVRPIGSLVKPAVYLSALERGYTLVSPIEDEPFSVDMPNGQVWQPQNFDKQPHGVVPLHRALAQSYNLSTARLGMDVGLDNVIKTLRQLGVEREIDPYPSLLLGAQGLPVAEVASVYQTIAANGFQMPLRSIRQVTDSSGVELSRYPFQVRQTVSGESVHLLQYAMQEVARSGTARSIYSSLPSDLNVGGKTGTSNDQRDSWFAGFTGNRLAVVWLGRDDNEPLPFTGSGGALKVWTEFMKNERPEPFITPVPEGVEYLWVDQETGYLSDERCQGAVQIPFLKGTKPQYRVDCGVEPVQNRGAEPLDWFRRWFRQE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP043869
EMBL· GenBank· DDBJ
QEQ97936.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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