A0A5P1EVE1 · A0A5P1EVE1_ASPOF
- ProteinATP-dependent 6-phosphofructokinase
- GenePFK
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids557 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Catalytic activity
- ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H+
Cofactor
Activity regulation
Allosterically activated by AMP.
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 152 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 215-216 | ATP (UniProtKB | ChEBI) | ||||
Sequence: RG | ||||||
Binding site | 240-243 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GDGT | ||||||
Binding site | 241 | Mg2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Site | 242 | Important for substrate specificity; cannot use PPi as phosphoryl donor | ||||
Sequence: G | ||||||
Binding site | 269-271 | substrate | ||||
Sequence: TID | ||||||
Active site | 271 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 314-316 | substrate | ||||
Sequence: MGR | ||||||
Binding site | 370 | substrate | ||||
Sequence: E | ||||||
Binding site | 427-430 | substrate | ||||
Sequence: YMIR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 6-phosphofructokinase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | fructose 6-phosphate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent 6-phosphofructokinase
- EC number
- Short namesATP-PFK ; Phosphofructokinase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Asparagales > Asparagaceae > Asparagoideae > Asparagus
Accessions
- Primary accessionA0A5P1EVE1
Proteomes
Genome annotation databases
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-26 | Disordered | ||||
Sequence: MESKPKSLDLSSNSNSNSTSSGILSQ | ||||||
Domain | 146-451 | Phosphofructokinase | ||||
Sequence: CIVTCGGLCPGLNTVIREIVCGLNHMYGVDKVFGIVDGYKGFYARNTVDLTPKSVDDIHKRGGTVLGTSRGGHDTMKIVDSIQDRGIHQVYIIGGDGTQKGASLIFEEIQRRGLKVAVAGIPKTIDNDIAVIDKSFGFDTAVGEAQRAINAAHVEASSVENGIGVVKLMGRYSGFIAMYATLASRDVDCCLIPESPFYLEGKGGLYEYIEKRLKENGHMVLVVAEGAGQELIAESLRSMDHQDASGNKLLLDVGLWLSQKIKDHFTNSGRMQITLKYIDPTYMIRAIPSIASDNVYCTLLAHSAIH |
Sequence similarities
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length557
- Mass (Da)61,308
- Last updated2020-02-26 v1
- ChecksumBD77E63B56BC461B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM007385 EMBL· GenBank· DDBJ | ONK69784.1 EMBL· GenBank· DDBJ | Genomic DNA |