A0A5N9ARE8 · A0A5N9ARE8_9CHLR

Function

function

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site232S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site261S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site282S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site325S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site352
Active site352Nucleophile
Site408Important for substrate specificity
Active site464Proton acceptor
Site465Important for substrate specificity
Site549Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular FunctionRNA methyltransferase activity
Molecular FunctionS-adenosylmethionine-dependent methyltransferase activity
Biological Processmethylation
Biological Processnucleotide metabolic process
Biological ProcessRNA modification
Biological ProcessRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dTTP/UTP pyrophosphatase
  • EC number
  • Short names
    dTTPase/UTPase
  • Alternative names
    • Nucleoside triphosphate pyrophosphatase
    • Nucleotide pyrophosphatase
      (Nucleotide PPase
      )

Gene names

    • Name
      maf
    • ORF names
      FI713_00730

Organism names

Accessions

  • Primary accession
    A0A5N9ARE8

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-61TRAM

Sequence similarities

Belongs to the Maf family. YhdE subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    65,877
  • Last updated
    2020-04-22 v1
  • Checksum
    ACAB66F480523D11
MTTFERGRRLQVVLEGMGRLGEAMVEVDGKPVFVFGGIPGEEVELEVIREHRHYVAAKVVKVDSASSFRIEPECKYFGLCTGCQWQHIGYQHQLELKRLAVEDALRRVGGILEVQVLPTLPSPNQLGYRNHARFTVGRREGVLGFVNRETRRFIEIDECLLMAPWINEALGKLKGHCSETSQVAIRYGSQSGDWLIQPTLSDPGVPFPTGQKNYLEMVRGVDFKVSSPAFFQVNIPQLERMVDLLRDALSLSGDETLVDAYAGVGTFASLLAPFAGKVIAIEESAAAISDAYENIALRDNVSIMKGKTENVLTDLQEMVDCIVLDPPRSGCQLEALSAVAKLAPRKVAYVSCDPQTLARDLKILTQGPYQIESVQPLDMFPQTHHVECLATLRLKTGHPITLASSSPRRIDILNDAGIPFNVIWPEGDEDLPGGRPEDHVQILALNKATQVAATLNRGLVIAGDTVVVDGSTVLGKPADQEAALSMLAGLRGKLHHVITGVAVVDATTMESTTGVKTSWVRMRNYTDKEARTFVESGEALDKAGAYAVQDELFHPAEYVEGCYFNVVGLPLCLTVDLLRQMGADVSEVTLPQGCTVVESRGQS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VFGM01000048
EMBL· GenBank· DDBJ
MQG02224.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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