A0A5N6KSW0 · A0A5N6KSW0_9ROSI
- ProteinRNA-directed RNA polymerase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids4089 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
Cofactor
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | Mre11 complex | |
Cellular Component | site of double-strand break | |
Molecular Function | 3'-5'-DNA exonuclease activity | |
Molecular Function | manganese ion binding | |
Molecular Function | RNA binding | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | single-stranded DNA endodeoxyribonuclease activity | |
Biological Process | double-strand break repair via homologous recombination | |
Biological Process | double-strand break repair via nonhomologous end joining | |
Biological Process | meiotic DNA double-strand break formation | |
Biological Process | mitochondrial double-strand break repair via homologous recombination | |
Biological Process | mitotic G2 DNA damage checkpoint signaling | |
Biological Process | mitotic intra-S DNA damage checkpoint signaling | |
Biological Process | regulatory ncRNA-mediated gene silencing | |
Biological Process | telomere maintenance |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRNA-directed RNA polymerase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fagales > Betulaceae > Carpinus
Accessions
- Primary accessionA0A5N6KSW0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 156-180 | Helical | ||||
Sequence: VAALVATSVWAMVLFLATASVGGVF |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1072-1249 | Mre11 DNA-binding | ||||
Sequence: FECETIPLKTVRPFVMKEIVLQEEPSMKSLAKKSDNRSEITRYLTSIVENLIEQAKTTWLETQEGEETDEDLKIPLPLVRLRVEYTAPEGGSFDCENPQRFSGRFAGRVANTHDVVQFHRKKTTVRKLKDNSDLPEEATMAALSLDTVKVEKLVREFLTAQSLTILPQNSFGDAVSQF | ||||||
Region | 1306-1497 | Disordered | ||||
Sequence: RARKVKPKPAHWDSDMDGAWEDQPGALALSDKEGDAEEEADPVPTPATRGRGRGRGKSSGTTRSTATTKRATPVPKPTARAASRRNKGPFDDDDSVEDNDVIMIDDDDDDDDENNGPAASTVRPSTKGPSSSRTSTRNAGAAAKRTTSRSSAAPRTNQRQTQLDFSQNPHPTRRANGAKKVVQSDDEISDDD | ||||||
Compositional bias | 1360-1377 | Polar residues | ||||
Sequence: RGKSSGTTRSTATTKRAT | ||||||
Compositional bias | 1398-1420 | Acidic residues | ||||
Sequence: DDSVEDNDVIMIDDDDDDDDENN | ||||||
Compositional bias | 1423-1478 | Polar residues | ||||
Sequence: AASTVRPSTKGPSSSRTSTRNAGAAAKRTTSRSSAAPRTNQRQTQLDFSQNPHPTR | ||||||
Region | 1744-1763 | Disordered | ||||
Sequence: RVKPNGRSGRPSKYSPTPSI | ||||||
Region | 1777-1800 | Disordered | ||||
Sequence: SPPGIRVTAGGRIVPDGLSPITSP | ||||||
Region | 2103-2164 | Disordered | ||||
Sequence: PTVVLPPPKTNKPDGPGHQSKRSHAVAIKAPEPVATEKRIALNPTSPSYQPSEDKESHTQGA | ||||||
Compositional bias | 2143-2161 | Polar residues | ||||
Sequence: ALNPTSPSYQPSEDKESHT | ||||||
Compositional bias | 2201-2233 | Polar residues | ||||
Sequence: QLNRGQSGSKHRESSSTASTADFFPQDAQDHST | ||||||
Region | 2201-2242 | Disordered | ||||
Sequence: QLNRGQSGSKHRESSSTASTADFFPQDAQDHSTTRYSYTDRD | ||||||
Region | 2450-2502 | Disordered | ||||
Sequence: GERASDPGYAPTHRRVSLPSFGPPGAPVNSPTSTPMSTTPKTGRASSESKFSP | ||||||
Compositional bias | 2480-2502 | Polar residues | ||||
Sequence: PTSTPMSTTPKTGRASSESKFSP | ||||||
Region | 2523-2561 | Disordered | ||||
Sequence: IGTQTSGSRIRRTEPYGSPLANRQPNSMRESSYGSPGET | ||||||
Compositional bias | 2541-2561 | Polar residues | ||||
Sequence: PLANRQPNSMRESSYGSPGET | ||||||
Region | 2603-2640 | Disordered | ||||
Sequence: FDGSTEETEVKRQGRMSISQPTQSDQVPNMTSRGTSPS | ||||||
Compositional bias | 2616-2640 | Polar residues | ||||
Sequence: GRMSISQPTQSDQVPNMTSRGTSPS | ||||||
Region | 2657-2685 | Disordered | ||||
Sequence: LKSPEPQAQSPASPQGSKQTSPSKCRVGW | ||||||
Compositional bias | 2662-2680 | Polar residues | ||||
Sequence: PQAQSPASPQGSKQTSPSK |
Sequence similarities
Belongs to the MRE11/RAD32 family.
Belongs to the RdRP family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length4,089
- Mass (Da)452,597
- Last updated2020-02-26 v1
- Checksum1B819237F1685188
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1360-1377 | Polar residues | ||||
Sequence: RGKSSGTTRSTATTKRAT | ||||||
Compositional bias | 1398-1420 | Acidic residues | ||||
Sequence: DDSVEDNDVIMIDDDDDDDDENN | ||||||
Compositional bias | 1423-1478 | Polar residues | ||||
Sequence: AASTVRPSTKGPSSSRTSTRNAGAAAKRTTSRSSAAPRTNQRQTQLDFSQNPHPTR | ||||||
Compositional bias | 2143-2161 | Polar residues | ||||
Sequence: ALNPTSPSYQPSEDKESHT | ||||||
Compositional bias | 2201-2233 | Polar residues | ||||
Sequence: QLNRGQSGSKHRESSSTASTADFFPQDAQDHST | ||||||
Compositional bias | 2480-2502 | Polar residues | ||||
Sequence: PTSTPMSTTPKTGRASSESKFSP | ||||||
Compositional bias | 2541-2561 | Polar residues | ||||
Sequence: PLANRQPNSMRESSYGSPGET | ||||||
Compositional bias | 2616-2640 | Polar residues | ||||
Sequence: GRMSISQPTQSDQVPNMTSRGTSPS | ||||||
Compositional bias | 2662-2680 | Polar residues | ||||
Sequence: PQAQSPASPQGSKQTSPSK |
Keywords
- Technical term