A0A5N5TTR6 · A0A5N5TTR6_9GAMM

  • Protein
    dITP/XTP pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13substrate
Active site69Proton acceptor
Binding site69Mg2+ (UniProtKB | ChEBI)
Binding site70substrate
Binding site153-156substrate
Binding site176substrate
Binding site181-182substrate

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      TUM17379_12400

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TUM17379
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella

Accessions

  • Primary accession
    A0A5N5TTR6

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    21,532
  • Last updated
    2022-01-19 v1
  • Checksum
    BA8127EA83D8FEB1
MKQIVLASGNKGKLKEFAEMFNAFNIEVLPQNQFDVPEVAETGTTFVENAIIKARHAAEITGLPAIADDSGLEVDALDGAPGIYSARYSGANATAEGNYNKLLGAIEATPAPRTARFQCVLVYMRHAKDPTPIICQAAWEGEIGFEPKGDNGHGYDPVFIPCGYQQTAAELSSDEKNHLSHRGKALKLLLEAFKQQGILG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024613
EMBL· GenBank· DDBJ
BCV44222.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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