A0A5N4APR5 · A0A5N4APR5_PHOPY

Function

function

Converts sphingomyelin to ceramide.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site191Zn2+ 1 (UniProtKB | ChEBI)
Binding site193Zn2+ 1 (UniProtKB | ChEBI)
Binding site263Zn2+ 2 (UniProtKB | ChEBI)
Binding site263Zn2+ 1 (UniProtKB | ChEBI)
Binding site303Zn2+ 2 (UniProtKB | ChEBI)
Binding site412Zn2+ 2 (UniProtKB | ChEBI)
Binding site446Zn2+ 2 (UniProtKB | ChEBI)
Binding site448Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentlysosome
Molecular Functionacid sphingomyelin phosphodiesterase activity
Molecular Functionhydrolase activity, acting on glycosyl bonds
Molecular Functionmetal ion binding
Biological Processceramide biosynthetic process
Biological Processsphingomyelin catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sphingomyelin phosphodiesterase
  • EC number

Gene names

    • ORF names
      PPYR_07199

Organism names

Accessions

  • Primary accession
    A0A5N4APR5

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_502446034518-612Sphingomyelin phosphodiesterase
Disulfide bond105↔116
Disulfide bond206↔211
Disulfide bond212↔234
Disulfide bond372↔420
Disulfide bond572↔576

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain70-156Saposin B-type

Sequence similarities

Belongs to the acid sphingomyelinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    612
  • Mass (Da)
    70,294
  • Last updated
    2020-02-26 v1
  • MD5 Checksum
    CD0781A222EBCA11B095F58B517A25DB
MYLRLVLIFALVQFSTPTTISDWKYNLYRGLQHYVRTGEESDQLRLTAREIAFPQLFRKSYVRKQRDMMESIVCPACDIGLGIVITARRAGASVETLGDIIEFICKSIIIESAEVCKGVVELNRDILGYIIDNKPDLTSERVCSILLQNFNCKDSNRTDWTIKIPPRLRNNAPQVQDPKPGKSYKILQLTDMHYDPDYKIGSNAVCVEPLCCQVHSPGLRSEDKAGYWGDYRGCDLPWHSVVDVLDHVVDQHGDVDLIYFTGDIINHKVWKTNIKENTEAISKVFKQLKETFGNLKIYPILGNHEPHPVNMFSSKFVDNNHSLSTRWIFELVAEEWSRWLPKETKQTILKGGYYTVLHRPGFRIIALNSNVCYTMNFWLFHDDEDPFGQLQWLADTLAKAEKLGERVHILSHVATGDATCLHNWAEEYTKIIYRFSHIISAQFNGHTHNDDTVILFTQDKKPEPVNIAFNGGSLTPYSDLNPNYKVYEVDSNTQNVLDFDTWSYNLTEANADPQISPQWKKLYSFKESFGLSSVTPNDVAKLVERMTKDPKLTESYFRFQSREADSSLALGCDSDCEIENICYMVTFVHGKNFQCQTFTDMYNSNRPKPKPT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VVIM01000005
EMBL· GenBank· DDBJ
KAB0799319.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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