A0A5N4APR5 · A0A5N4APR5_PHOPY
- ProteinSphingomyelin phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids612 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts sphingomyelin to ceramide.
Catalytic activity
- a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 191 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 193 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 263 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 263 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 303 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 412 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 446 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 448 | Zn2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | lysosome | |
Molecular Function | acid sphingomyelin phosphodiesterase activity | |
Molecular Function | hydrolase activity, acting on glycosyl bonds | |
Molecular Function | metal ion binding | |
Biological Process | ceramide biosynthetic process | |
Biological Process | sphingomyelin catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSphingomyelin phosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Elateriformia > Elateroidea > Lampyridae > Lampyrinae > Photinus
Accessions
- Primary accessionA0A5N4APR5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-17 | ||||
Chain | PRO_5024460345 | 18-612 | Sphingomyelin phosphodiesterase | ||
Disulfide bond | 105↔116 | ||||
Disulfide bond | 206↔211 | ||||
Disulfide bond | 212↔234 | ||||
Disulfide bond | 372↔420 | ||||
Disulfide bond | 572↔576 | ||||
Keywords
- PTM
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length612
- Mass (Da)70,294
- Last updated2020-02-26 v1
- MD5 ChecksumCD0781A222EBCA11B095F58B517A25DB
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VVIM01000005 EMBL· GenBank· DDBJ | KAB0799319.1 EMBL· GenBank· DDBJ | Genomic DNA |