A0A5M9N0H7 · A0A5M9N0H7_9EURO

  • Protein
    Adenine deaminase
  • Gene
    AAH1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site19Zn2+ (UniProtKB | ChEBI); catalytic
Binding site21Zn2+ (UniProtKB | ChEBI); catalytic
Binding site208Zn2+ (UniProtKB | ChEBI); catalytic
Active site211Proton donor
Site231Important for catalytic activity
Binding site288Zn2+ (UniProtKB | ChEBI); catalytic
Binding site289substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Function2'-deoxyadenosine deaminase activity
Molecular Functionadenine deaminase activity
Molecular Functionadenosine deaminase activity
Molecular Functionoxidoreductase activity
Molecular Functionzinc ion binding
Biological Processadenine catabolic process
Biological Processhypoxanthine salvage
Biological Processnucleotide metabolic process
Biological Processpurine ribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenine deaminase
  • EC number
  • Short names
    ADE
  • Alternative names
    • Adenine aminohydrolase
      (AAH
      )

Gene names

    • Name
      AAH1
    • ORF names
      ATNIH1004_003135

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NIH1004
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati

Accessions

  • Primary accession
    A0A5M9N0H7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain14-325Adenosine deaminase
Region747-796Disordered

Sequence similarities

Belongs to the complex I 24 kDa subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    796
  • Mass (Da)
    88,001
  • Last updated
    2020-02-26 v1
  • Checksum
    96C74566527625D6
MCQSDLHDFLHGLPKCEHHVHLEGCLTPELIFHLAERNSVQLPKDPAYETVETLTQRYGHFTSLDDFLGFYFYGMSVLLQESDFADLAWAYFQKAHADGVHHAEVFFDPQVHRDRGIPYATIVSGFVAGCKRAEKELGLTTRLILCFVRHLPVESAANVYEEALVHQHFDTDIVHGLGWSSTEIGPPKDMFRELYSSASARGIRLTAHAGEEGDASYISTALELGAQRIDHGIRLVEDPVLMERVAQEGILLTVCPLSNVQLRCVDSVAQVPIRKFLDAGVKFSINSDDPAYFGGYILDNYCAVQEAFQLSIEDWRVIAENSIDSVEDTIYSSNSRNRHGCGTITQLSQDFGRRILPASRSLLHFSFLPPHTSSILRNTGRTYIYSQARVMSLNAADDRYKLVFFVPHSHLDSVKEAVFATGAGTFPGGKYSKCCFQTPGQGQFMPADGANPTIGAVGTLEYVEEMKVEMICVGRSVMLHAVDALITAHPYEEHPQNASSTPIAAESFIFVSSSPTSSLSQFIPSPPPAMASRIFPAVPRVGRQLFQSVPKSQCRPFSAGPQRCSDSLAVHRNKPTNNPSIPFKFSEQNLKLADEILKRYPPQYKKAAVMPLLDLGQRQHGYTSISVMNEVARLLEMPPMRVYEVATFYTMYNREPVGKYFVQLCTTTPCQLGGCGSDKIVKAITEHLGITPGHTTEDGLFTFIEVECLGACVNAPMVQINDDYYEDLTPESIKTLLTALKESATATDAGKQVPAPGPMSGRQSCENSAGLTSLREPVWDPETMMRKDGALDAQQQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QUQM01000001
EMBL· GenBank· DDBJ
KAA8650449.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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