A0A5M9N0H7 · A0A5M9N0H7_9EURO
- ProteinAdenine deaminase
- GeneAAH1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids796 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
Catalytic activity
- adenine + H+ + H2O = hypoxanthine + NH4+
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 19 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 21 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 208 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 211 | Proton donor | ||||
Sequence: E | ||||||
Site | 231 | Important for catalytic activity | ||||
Sequence: H | ||||||
Binding site | 288 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 289 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | 2'-deoxyadenosine deaminase activity | |
Molecular Function | adenine deaminase activity | |
Molecular Function | adenosine deaminase activity | |
Molecular Function | oxidoreductase activity | |
Molecular Function | zinc ion binding | |
Biological Process | adenine catabolic process | |
Biological Process | hypoxanthine salvage | |
Biological Process | nucleotide metabolic process | |
Biological Process | purine ribonucleoside monophosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenine deaminase
- EC number
- Short namesADE
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionA0A5M9N0H7
Proteomes
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-325 | Adenosine deaminase | ||||
Sequence: PKCEHHVHLEGCLTPELIFHLAERNSVQLPKDPAYETVETLTQRYGHFTSLDDFLGFYFYGMSVLLQESDFADLAWAYFQKAHADGVHHAEVFFDPQVHRDRGIPYATIVSGFVAGCKRAEKELGLTTRLILCFVRHLPVESAANVYEEALVHQHFDTDIVHGLGWSSTEIGPPKDMFRELYSSASARGIRLTAHAGEEGDASYISTALELGAQRIDHGIRLVEDPVLMERVAQEGILLTVCPLSNVQLRCVDSVAQVPIRKFLDAGVKFSINSDDPAYFGGYILDNYCAVQEAFQLSIEDWRVIAENSIDS | ||||||
Region | 747-796 | Disordered | ||||
Sequence: TDAGKQVPAPGPMSGRQSCENSAGLTSLREPVWDPETMMRKDGALDAQQQ |
Sequence similarities
Belongs to the complex I 24 kDa subunit family.
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length796
- Mass (Da)88,001
- Last updated2020-02-26 v1
- Checksum96C74566527625D6