A0A5M4D5D4 · A0A5M4D5D4_9CYAN

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

162650100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site408Zn2+ (UniProtKB | ChEBI); catalytic
Active site409
Binding site412Zn2+ (UniProtKB | ChEBI); catalytic
Binding site484Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane-derived thylakoid membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      hflB
    • Synonyms
      ftsH
    • ORF names
      EDM82_07820

Organism names

Accessions

  • Primary accession
    A0A5M4D5D4

Proteomes

Subcellular Location

Cellular thylakoid membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane89-110Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain177-317AAA+ ATPase
Region596-626Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    626
  • Mass (Da)
    68,914
  • Last updated
    2020-02-26 v1
  • Checksum
    91D6D63F89B2FFF9
MLVMFLSYSQSGNRVTFNDLESHILAQDLVANVPVVVRDDAIIAEIKQPETRSGRQTVIVQMNSATREIYVARLRELDVKMLARAPSPWFQLLIFFGPVLLIMLLIWMMVSRGLRGAASGAGMLGNFGKSRHQRLTKEMTGVTFKDVAGIDEAKDEVKEIIEFLRNPKKFTRLGGRIPRGVLLVGDPGCGKTLLAKAIAGEADVPFFSISGSDFVEMFVGVGASRVRDLFKQAKESAPCIIFLDEIDAVGRRRGGGFSGGGNDEREQTLNAILVEMDGFTSSDGVIVIAATNRGDVLDPALTRPGRFDRQITVPLPDLKGRLEILKVHSKKVKLGEDIDLEKIARGTPMFSGADLAAIINEGAIAATMQNKDFIEHEDLEEARDKVKFGRARKSRNREKEENRLVAYHEAGHAVLQALLKDADPLHKVTIIPRGSAGGATFSLPEKDRMGYSKKWLLATMRVTCGGRIAEERAMGDVSSGASQDIMQATQLARTMILDWGMSSRLGFVRYAPLDTREMFLPEKDYSEETARTIDQEVRQLIDEAYKDAVQILDANWDKVVAVAEALLKHETLTADEVQTLMRGERLDKPSVAELLEAETRNGRERPVPRGGGGQTDFPPEAVPSPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RHKP01000009
EMBL· GenBank· DDBJ
KAA0215409.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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