A0A5K1JR95 · A0A5K1JR95_9APHY

  • Protein
    NAD-dependent histone deacetylase SIR2
  • Gene
    G4MS03
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Features

Showing features for active site, binding site.

132350100150200250300
Type
IDPosition(s)Description
Active site105Proton acceptor
Binding site113Zn2+ (UniProtKB | ChEBI)
Binding site116Zn2+ (UniProtKB | ChEBI)
Binding site137Zn2+ (UniProtKB | ChEBI)
Binding site140Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmating-type region heterochromatin
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functiontransferase activity
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpericentric heterochromatin formation
Biological Processregulation of DNA repair
Biological Processreplication-born double-strand break repair via sister chromatid exchange

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • NAD-dependent histone deacetylase SIR2

Gene names

    • Name
      G4MS03

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Polyporales > Polyporaceae > Ganoderma

Accessions

  • Primary accession
    A0A5K1JR95

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain1-250Deacetylase sirtuin-type
Region57-89Disordered
Compositional bias65-89Polar residues

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    323
  • Mass (Da)
    35,636
  • Last updated
    2019-12-11 v1
  • MD5 Checksum
    043FA95FCA3C49553685C293E9B0045A
MIAELSQLSEVAEPTAFHRFLRALDDRRSLLRVYTQNIDALEEKSGLTFGIPAEEIKGTSHRPSKGNAPAASSEVATTDICPQDDSTTSQIPLPLKETPKCIPLHGTLRSMHCMTCGHSCPLRHYINSLVSGVPPPCPQCTALEQTRQLIGKRAHSIGKLRPSIVLYNEDHKDGENVGKVVRKDLLGSSKGKSRTGADLLLVVGTSLRVPGTKRIVREFAKVVRSRHAAMDPSNLLADEPALCTRGLMGPTSPPQPSTERYKEPPVQTIYLNLDFPTPTSQWEGVFDVWIRGDAQAFAGMVHEELEKEKLAKEVGHERKRKRE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias65-89Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR723792
EMBL· GenBank· DDBJ
VWO94137.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help