A0A5J6Z8B2 · A0A5J6Z8B2_9CORY

Function

function

Catalyzes the conversion of lactate to pyruvate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Activity regulation

Allosterically activated by fructose 1,6-bisphosphate (FBP).

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13-18NAD+ (UniProtKB | ChEBI)
Binding site17NAD+ (UniProtKB | ChEBI)
Binding site38NAD+ (UniProtKB | ChEBI)
Binding site43NAD+ (UniProtKB | ChEBI)
Binding site69NAD+ (UniProtKB | ChEBI)
Binding site83-84NAD+ (UniProtKB | ChEBI)
Binding site86substrate
Binding site92substrate
Binding site99NAD+ (UniProtKB | ChEBI)
Binding site122-124NAD+ (UniProtKB | ChEBI)
Binding site124-127substrate
Binding site147NAD+ (UniProtKB | ChEBI)
Binding site152-155substrate
Binding site157beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Binding site172beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Active site179Proton acceptor
Binding site240substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-lactate dehydrogenase activity
Biological Processglycolytic process
Biological Processlactate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase
  • EC number
  • Short names
    L-LDH

Gene names

    • Name
      ldhA
    • Synonyms
      ldh
    • ORF names
      CUROG_00890

Organism names

  • Taxonomic identifier
  • Strain
    • LMM 1652
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium

Accessions

  • Primary accession
    A0A5J6Z8B2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue231Phosphotyrosine

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-146Lactate/malate dehydrogenase N-terminal
Domain149-318Lactate/malate dehydrogenase C-terminal

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    335
  • Mass (Da)
    35,555
  • Last updated
    2019-12-11 v1
  • Checksum
    DC99B1B2B1A53375
MTLTTGAKIVLIGAGDVGIAYAYALVNQGLCDHLAIIDINERKTWGHVQDLNHAVPWAGHSVKVSVGTYEDCADAAVVVNCAGVAQKPGETRLDLVGRNVAIFEDIVGKVMASGFNGIFLVATNPVDILSFATWKLSGLPSSQVIGSGTILDTARYRYSLGRYFDLAPSSVHAYVIGEHGDTELPVLSAGSAGGVPLKKMLRARAEEKAQDGALPIDDASAIFEETRDAAYEIIQAKGSTSFGIGMGLARITRAILHNQDVVLPVSAFLEGHYGLEDVYIGTPAVIDRRGVRHVVELDLDEDENQKFQHSARVLKDVMAGAGLVASSGNKEGKSQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP045032
EMBL· GenBank· DDBJ
QFQ01579.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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