A0A5J6EIP3 · A0A5J6EIP3_9CNID
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids145 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Scleractinia > Faviina > Lobophylliidae > Lobophyllia
Accessions
- Primary accessionA0A5J6EIP3
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-35 | Helical | ||||
Sequence: TAHAFIMIFFLVMPVMIGGFGNWLVPLYIG | ||||||
Transmembrane | 47-65 | Helical | ||||
Sequence: ISFWLLPPALFLLLGSAFV | ||||||
Transmembrane | 93-116 | Helical | ||||
Sequence: VIFSLHLAGVSSILGAINFITTIF | ||||||
Transmembrane | 128-144 | Helical | ||||
Sequence: MPLFVWSILITAFLLLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-145 | Cytochrome oxidase subunit I profile | ||||
Sequence: YNVIVTAHAFIMIFFLVMPVMIGGFGNWLVPLYIGAPDMAFPRLNNISFWLLPPALFLLLGSAFVEQGAGTGWTVYPPLSDIYAHSGGSVDMVIFSLHLAGVSSILGAINFITTIFNMRAPGVSFNRMPLFVWSILITAFLLLLS |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length145
- Mass (Da)15,843
- Last updated2019-12-11 v1
- ChecksumE7CB871D3C73EF8F
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: Y | ||||||
Non-terminal residue | 145 | |||||
Sequence: S |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MK648046 EMBL· GenBank· DDBJ | QEU63395.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648048 EMBL· GenBank· DDBJ | QEU63397.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648049 EMBL· GenBank· DDBJ | QEU63398.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648050 EMBL· GenBank· DDBJ | QEU63399.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648051 EMBL· GenBank· DDBJ | QEU63400.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648053 EMBL· GenBank· DDBJ | QEU63402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648054 EMBL· GenBank· DDBJ | QEU63403.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648055 EMBL· GenBank· DDBJ | QEU63404.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648056 EMBL· GenBank· DDBJ | QEU63405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648057 EMBL· GenBank· DDBJ | QEU63406.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648058 EMBL· GenBank· DDBJ | QEU63407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648059 EMBL· GenBank· DDBJ | QEU63408.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648060 EMBL· GenBank· DDBJ | QEU63409.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648061 EMBL· GenBank· DDBJ | QEU63410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648062 EMBL· GenBank· DDBJ | QEU63411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648063 EMBL· GenBank· DDBJ | QEU63412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648064 EMBL· GenBank· DDBJ | QEU63413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648065 EMBL· GenBank· DDBJ | QEU63414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648067 EMBL· GenBank· DDBJ | QEU63416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648072 EMBL· GenBank· DDBJ | QEU63421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648074 EMBL· GenBank· DDBJ | QEU63423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648075 EMBL· GenBank· DDBJ | QEU63424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648076 EMBL· GenBank· DDBJ | QEU63425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648077 EMBL· GenBank· DDBJ | QEU63426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648079 EMBL· GenBank· DDBJ | QEU63428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648080 EMBL· GenBank· DDBJ | QEU63429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648081 EMBL· GenBank· DDBJ | QEU63430.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648082 EMBL· GenBank· DDBJ | QEU63431.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648083 EMBL· GenBank· DDBJ | QEU63432.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648084 EMBL· GenBank· DDBJ | QEU63433.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648085 EMBL· GenBank· DDBJ | QEU63434.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648086 EMBL· GenBank· DDBJ | QEU63435.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648087 EMBL· GenBank· DDBJ | QEU63436.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648088 EMBL· GenBank· DDBJ | QEU63437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648089 EMBL· GenBank· DDBJ | QEU63438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648090 EMBL· GenBank· DDBJ | QEU63439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648092 EMBL· GenBank· DDBJ | QEU63441.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648093 EMBL· GenBank· DDBJ | QEU63442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648095 EMBL· GenBank· DDBJ | QEU63444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648097 EMBL· GenBank· DDBJ | QEU63446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK648098 EMBL· GenBank· DDBJ | QEU63447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK622914 EMBL· GenBank· DDBJ | QIM55778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK622918 EMBL· GenBank· DDBJ | QIM55782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK622919 EMBL· GenBank· DDBJ | QIM55783.1 EMBL· GenBank· DDBJ | Genomic DNA |