A0A5J6EIP3 · A0A5J6EIP3_9CNID

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Scleractinia > Faviina > Lobophylliidae > Lobophyllia

Accessions

  • Primary accession
    A0A5J6EIP3

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-35Helical
Transmembrane47-65Helical
Transmembrane93-116Helical
Transmembrane128-144Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-145Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    145
  • Mass (Da)
    15,843
  • Last updated
    2019-12-11 v1
  • Checksum
    E7CB871D3C73EF8F
YNVIVTAHAFIMIFFLVMPVMIGGFGNWLVPLYIGAPDMAFPRLNNISFWLLPPALFLLLGSAFVEQGAGTGWTVYPPLSDIYAHSGGSVDMVIFSLHLAGVSSILGAINFITTIFNMRAPGVSFNRMPLFVWSILITAFLLLLS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue145

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK648046
EMBL· GenBank· DDBJ
QEU63395.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648048
EMBL· GenBank· DDBJ
QEU63397.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648049
EMBL· GenBank· DDBJ
QEU63398.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648050
EMBL· GenBank· DDBJ
QEU63399.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648051
EMBL· GenBank· DDBJ
QEU63400.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648053
EMBL· GenBank· DDBJ
QEU63402.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648054
EMBL· GenBank· DDBJ
QEU63403.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648055
EMBL· GenBank· DDBJ
QEU63404.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648056
EMBL· GenBank· DDBJ
QEU63405.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648057
EMBL· GenBank· DDBJ
QEU63406.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648058
EMBL· GenBank· DDBJ
QEU63407.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648059
EMBL· GenBank· DDBJ
QEU63408.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648060
EMBL· GenBank· DDBJ
QEU63409.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648061
EMBL· GenBank· DDBJ
QEU63410.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648062
EMBL· GenBank· DDBJ
QEU63411.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648063
EMBL· GenBank· DDBJ
QEU63412.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648064
EMBL· GenBank· DDBJ
QEU63413.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648065
EMBL· GenBank· DDBJ
QEU63414.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648067
EMBL· GenBank· DDBJ
QEU63416.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648072
EMBL· GenBank· DDBJ
QEU63421.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648074
EMBL· GenBank· DDBJ
QEU63423.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648075
EMBL· GenBank· DDBJ
QEU63424.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648076
EMBL· GenBank· DDBJ
QEU63425.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648077
EMBL· GenBank· DDBJ
QEU63426.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648079
EMBL· GenBank· DDBJ
QEU63428.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648080
EMBL· GenBank· DDBJ
QEU63429.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648081
EMBL· GenBank· DDBJ
QEU63430.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648082
EMBL· GenBank· DDBJ
QEU63431.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648083
EMBL· GenBank· DDBJ
QEU63432.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648084
EMBL· GenBank· DDBJ
QEU63433.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648085
EMBL· GenBank· DDBJ
QEU63434.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648086
EMBL· GenBank· DDBJ
QEU63435.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648087
EMBL· GenBank· DDBJ
QEU63436.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648088
EMBL· GenBank· DDBJ
QEU63437.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648089
EMBL· GenBank· DDBJ
QEU63438.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648090
EMBL· GenBank· DDBJ
QEU63439.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648092
EMBL· GenBank· DDBJ
QEU63441.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648093
EMBL· GenBank· DDBJ
QEU63442.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648095
EMBL· GenBank· DDBJ
QEU63444.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648097
EMBL· GenBank· DDBJ
QEU63446.1
EMBL· GenBank· DDBJ
Genomic DNA
MK648098
EMBL· GenBank· DDBJ
QEU63447.1
EMBL· GenBank· DDBJ
Genomic DNA
MK622914
EMBL· GenBank· DDBJ
QIM55778.1
EMBL· GenBank· DDBJ
Genomic DNA
MK622918
EMBL· GenBank· DDBJ
QIM55782.1
EMBL· GenBank· DDBJ
Genomic DNA
MK622919
EMBL· GenBank· DDBJ
QIM55783.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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