A0A5I9C580 · A0A5I9C580_SALET

Function

function

Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O2 and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site29Involved in heme-bound ligand stabilization and O-O bond activation
Site84Influences the redox potential of the prosthetic heme and FAD groups
Binding site85Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); proximal binding residue
Active site95Charge relay system
Active site135Charge relay system
Binding site188FAD (UniProtKB | ChEBI)
Binding site204-207FAD (UniProtKB | ChEBI)
Binding site268-273NADP+ (UniProtKB | ChEBI)
Site388Influences the redox potential of the prosthetic heme and FAD groups
Binding site389-392FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionFAD binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionnitric oxide dioxygenase NAD(P)H activity
Molecular Functionoxygen binding
Molecular Functionoxygen carrier activity
Biological Processresponse to nitrosative stress
Biological Processresponse to toxic substance

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Flavohemoprotein
  • Alternative names
    • Flavohemoglobin
    • Hemoglobin-like protein
    • Nitric oxide dioxygenase
      (NO oxygenase
      ; NOD
      ) (EC:1.14.12.17
      ) . EC:1.14.12.17 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      hmpA
    • Synonyms
      hmp
    • ORF names
      APM01_03320
      , DN927_15185
      , DOG83_13580
      , DU046_16185
      , DYS13_07205
      , DYT81_07415
      , E5908_19285
      , EWI81_19885

Organism names

  • Taxonomic identifier
  • Strains
    • FSIS11811772
    • FSIS11812504
    • FSIS31800512
    • FSIS31800555
    • FSIS31800800
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    A0A5I9C580

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain1-134Globin
Region147-396Reductase
Domain150-255FAD-binding FR-type

Domain

Consists of two distinct domains; an N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.

Sequence similarities

Belongs to the globin family. Two-domain flavohemoproteins subfamily.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    396
  • Mass (Da)
    44,015
  • Last updated
    2019-12-11 v1
  • Checksum
    9547ED7705303AAC
MLDAQTIATVKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNAIAAYASNIENLPALLPAVEKIAQKHTSFQIKPEQYNIVGTHLLATLDEMFNPGQEVLDAWGKAYGVLANVFIHREAEIYHENASKNGGWEGTRPFRIVAKIPRSALITSFEFEPVDGGTVAEYRPGQYLGVWLKPEGFAHQEIRQYSLTRKPDGKGYRIAVKREDGGQVSNWLHHHASVGDVVHLAAPAGDFFMNVAADTPVSLISAGVGQTPMLAMLDTLAKEQHTAQVNWFHAAENGDVHAFADEVSELGRTLPRFTAHTWYREPTEADRAQRVFDSEGLMDLSKLEAAISDPAMQFYLCGPVGFMQFAAKQLVSLGVNNENIHYECFGPHKVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHXHM010000043
EMBL· GenBank· DDBJ
ECB3379159.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHYZU010000019
EMBL· GenBank· DDBJ
ECB8846762.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKIXE010000002
EMBL· GenBank· DDBJ
ECS2227393.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKLKV010000018
EMBL· GenBank· DDBJ
ECT0133359.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKLWJ010000050
EMBL· GenBank· DDBJ
ECT1543963.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKMFT010000018
EMBL· GenBank· DDBJ
ECT2690872.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKSPP010000010
EMBL· GenBank· DDBJ
ECV1596635.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKSBI010000018
EMBL· GenBank· DDBJ
ECV3389669.1
EMBL· GenBank· DDBJ
Genomic DNA

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Disclaimer

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