A0A5I6L3V5 · A0A5I6L3V5_SALET

Function

function

Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate acid metabolism; galactarate degradation; D-glycerate from galactarate: step 2/3.

Features

Showing features for active site, site, binding site.

Type
IDPosition(s)Description
Active site50Proton acceptor
Site75Transition state stabilizer
Site89Increases basicity of active site His
Binding site151substrate
Binding site153Mg2+ (UniProtKB | ChEBI)
Binding site178substrate
Binding site179Mg2+ (UniProtKB | ChEBI)
Binding site179substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function2-dehydro-3-deoxyglucarate aldolase activity
Molecular Functionmagnesium ion binding
Biological ProcessD-glucarate catabolic process
Biological Processgalactarate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-keto-4-deoxy-D-glucarate aldolase
  • EC number
  • Short names
    KDGluc aldolase
    ; KDGlucA
  • Alternative names
    • 2-dehydro-3-deoxy-D-glucarate aldolase
    • 2-keto-3-deoxy-D-glucarate aldolase
    • 5-dehydro-4-deoxy-D-glucarate aldolase
    • Alpha-keto-beta-deoxy-D-glucarate aldolase

Gene names

    • Name
      garL
    • ORF names
      EKG43_18605
      , G2172_20800

Organism names

Accessions

  • Primary accession
    A0A5I6L3V5

Subcellular Location

Interaction

Subunit

Homohexamer; trimer of dimers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-244HpcH/HpaI aldolase/citrate lyase

Sequence similarities

Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    256
  • Mass (Da)
    27,321
  • Last updated
    2019-12-11 v1
  • Checksum
    41EFEBE9EE3A2AFA
MNNAIFPNKFKAALAAQQVQIGCWSALASPITTEVLGLAGFDWLVLDGEHAPNDVTTLIPQLMALKGSASAPVVRVPTNEPVIIKRMLDIGFYNFLIPFVETQEEAARAVASTRYPPEGIRGVSVSHRANMFGTVPDYFAQSNKNITIIVQIESQLGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGNASHPDVQQTIQHIFARAKAHGKPCGILAPVEADARRYLEWGATFVAVGSDLGAFRASTQKLADTFKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHUCI010000014
EMBL· GenBank· DDBJ
ECA3602891.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAQUJ010000008
EMBL· GenBank· DDBJ
HAE0919297.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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