A0A5I2WV80 · A0A5I2WV80_SALET

Function

function

mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Divalent metal cations. Mg2+ or Mn2+.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site69substrate
Binding site98Zn2+ (UniProtKB | ChEBI)
Binding site101Zn2+ (UniProtKB | ChEBI)
Binding site111substrate
Binding site116Zn2+ (UniProtKB | ChEBI)
Binding site119Zn2+ (UniProtKB | ChEBI)
Binding site124substrate
Binding site158a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site174a divalent metal cation 2 (UniProtKB | ChEBI)
Binding site174a divalent metal cation 3 (UniProtKB | ChEBI)
Binding site178a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site178a divalent metal cation 3 (UniProtKB | ChEBI)
Binding site192-199substrate
Binding site219a divalent metal cation 3 (UniProtKB | ChEBI)
Binding site219a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site241substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular FunctionNAD+ diphosphatase activity
Molecular FunctionNADH pyrophosphatase activity
Molecular Functionzinc ion binding
Biological ProcessNAD catabolic process
Biological ProcessNADH metabolic process
Biological ProcessNADP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-capped RNA hydrolase NudC
  • EC number
  • Short names
    DeNADding enzyme NudC
  • Alternative names
    • NADH pyrophosphatase
      (EC:3.6.1.22
      ) . EC:3.6.1.22 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      nudC
    • ORF names
      APM01_23080
      , BFV08_22450
      , DM677_23175
      , DN927_22070
      , DOG83_22505
      , DPE57_22935
      , DQK10_24005
      , DYS13_21830
      , DYT81_20305
      , E5908_22465
      , EWI81_21765
      , G4R07_004403

Organism names

  • Taxonomic identifier
  • Strains
    • 146074
    • 275776
    • 298956
    • M210
    • FSIS11812504
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    A0A5I2WV80

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain125-248Nudix hydrolase
Motif159-180Nudix box

Sequence similarities

Belongs to the Nudix hydrolase family. NudC subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    257
  • Mass (Da)
    29,593
  • Last updated
    2019-12-11 v1
  • Checksum
    05C99052BD43DD3D
MDRIIEKLESGWWIVSHEQKLWLPYGELPHGLAANFDLVGQRALRIGEWQGEPVWLVLQHRRHDMGSVRQVIDQDAGLFQLAGRGVQLAEFYRSHKFCGYCGHPMHPSKTEWAMLCSHCRERYYPQIAPCIIVAIRREDSILLAQHVRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGDIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGVGK010000039
EMBL· GenBank· DDBJ
EBS3934698.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHDUY010000030
EMBL· GenBank· DDBJ
EBU9895995.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHXHM010000054
EMBL· GenBank· DDBJ
ECB3379513.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHYZU010000033
EMBL· GenBank· DDBJ
ECB8847373.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKIXE010000028
EMBL· GenBank· DDBJ
ECS2231151.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKLKV010000039
EMBL· GenBank· DDBJ
ECT0134668.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKMFT010000094
EMBL· GenBank· DDBJ
ECT2693329.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKNWZ010000014
EMBL· GenBank· DDBJ
ECT7930094.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKSPP010000061
EMBL· GenBank· DDBJ
ECV1599414.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKSBI010000052
EMBL· GenBank· DDBJ
ECV3391360.1
EMBL· GenBank· DDBJ
Genomic DNA
DAATIJ010000017
EMBL· GenBank· DDBJ
HAE8739171.1
EMBL· GenBank· DDBJ
Genomic DNA
RVCL01000025
EMBL· GenBank· DDBJ
MLO07687.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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