A0A5I0MB31 · A0A5I0MB31_SALET

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site228Proton donor; for transglycosylase activity
Active site505Acyl-ester intermediate; for transpeptidase activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentpeptidoglycan-based cell wall
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1B
  • Short names
    PBP-1b
    ; PBP1b
  • Alternative names
    • Murein polymerase

Gene names

    • Name
      mrcB
    • ORF names
      B6B85_19000

Organism names

Accessions

  • Primary accession
    A0A5I0MB31

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane60-81Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-55Disordered
Domain1-74Transglycosylase PBP1b N-terminal transmembrane
Domain108-192Bifunctional transglycosylase second
Domain204-374Glycosyl transferase family 51
Domain468-710Penicillin-binding protein transpeptidase
Compositional bias793-820Polar residues
Region793-839Disordered

Sequence similarities

In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    839
  • Mass (Da)
    93,739
  • Last updated
    2019-12-11 v1
  • MD5 Checksum
    B0277555BED7E3AE92BD8AE380357310
MAGNDREPIGRKGKPSRPVKQKVSRRRQHDDDYDDDYEDEEPMPRKGKGKGRKPRGKRGWLWLLLKLFIVFVVLFAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMPVSKNEMVKLLEATQYRLVTKMTRPGEFTVQANSIEMIRRPFDFPDSKEGQVRARLTFSDGRLETIVNLDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSKDRILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQKIIDQELYDMLSARPLGVQPRGGVISPQPAFMQMVRQELQAKLGDKIKDLSGVKIFTTFDSVAQDAAEKAVVEGIPALKKQRKLSDLETAMVVVDRFSGEVRAMVGGAEPQYAGYNRAMQARRSIGSLAKPATYLTALSQPNLYRLNTWIADAPISLRQPNGQVWSPQNDDRRYSESGKVMLVDALTRSMNVPTVNLGMALGLPAVTDTWTKLGVPKDQLNPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGKVLYQSYPQAERAVPAQAAYLTLWTMQQVVQRGTGRQLGAKYPGLHLAGKTGTTNNNVDTWFAGIDGSQVTITWVGRDNNQPTKLYGASGAMAIYQRYLANQTPTPLVLTPPEDVVDMGVDYDGNFVCSGGMRTLPVWTDDPNTLCQQGEMMQQQQPSGNPFDQSSQPQQPAQQQPPKEEKSDGVAGWIKEMFGGN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias793-820Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAMGEW010000027
EMBL· GenBank· DDBJ
EDH0518239.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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