A0A5H7MDF3 · A0A5H7MDF3_SALET

Function

function

Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

GO annotations

AspectTerm
Molecular Function[protein-PII] uridylyltransferase activity
Molecular Functionphosphoric diester hydrolase activity
Biological Processregulation of nitrogen utilization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional uridylyltransferase/uridylyl-removing enzyme
  • Short names
    UTase/UR
  • Alternative names
    • Bifunctional [protein-PII] modification enzyme
    • Bifunctional nitrogen sensor protein

Including 2 domains:

  • Recommended name
    [Protein-PII] uridylyltransferase
  • EC number
  • Short names
    PII uridylyltransferase
    ; UTase
  • Recommended name
    [Protein-PII]-UMP uridylyl-removing enzyme
  • EC number
  • Short names
    UR

Gene names

    • Name
      glnD
    • ORF names
      APM01_12850
      , APM92_10925
      , BFV08_09080
      , DM677_07400
      , DN927_18940
      , DOG83_17085
      , DPE57_07870
      , DQK10_13070
      , DYS13_12820
      , DYT81_06190
      , E5908_13770
      , EWI81_11765
      , G4R07_002621

Organism names

  • Taxonomic identifier
  • Strains
    • 146074
    • 275776
    • 298956
    • M210
    • FSIS11812504
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    A0A5H7MDF3

Proteomes

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-18Polar residues
Region1-21Disordered
Region1-349Uridylyltransferase
Region350-708Uridylyl-removing
Domain468-590HD
Domain709-784ACT
Domain816-890ACT

Domain

Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.

Sequence similarities

Belongs to the GlnD family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    890
  • Mass (Da)
    102,195
  • Last updated
    2019-12-11 v1
  • Checksum
    2B147DE4DD077460
MNTLPEQHANTALPTLPDQPQNPGVWPRAELTVAGIKARIDIFQHWLGEAFDSGICAEQLIEARTEFIDQLLQRLWIEAGFGQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDEQAQKVGELLTLLWDVKLDVGHSVRTLEECLLEGLSDLTVATNLIETRLLIGDVALFLALQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTPAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNDPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPVDDEFQLRGTLIDLRDDTLFIREPQAILRMFYMMVRNSAITGIYSTTLRHLRHARRHLSQPLCYIPEARTLFLSMLRHPGAVSRGLLPMHRHSVLWAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFAKEETRQRHPLCVDLWPRLPHPELILIAALFHDIAKGRGGDHSVLGAQDVLTFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTETRLRFLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEAALHKIWTRCRANYFVRHSPNQLAWHARHLLQHDLSQPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLAADRHDVIRTGLEQTITQRSWQPPQPRRQPAKLRHFTVETEVNFLPTHTDRKSFMELIALDQPGLLARVGQIFADLGISLHGARITTIGERVEDLFIIATADRRALNNVLQLEVQQRLTAALNPNDKG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-18Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGVGK010000006
EMBL· GenBank· DDBJ
EBS3931810.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHDUY010000004
EMBL· GenBank· DDBJ
EBU9892977.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHXHM010000018
EMBL· GenBank· DDBJ
ECB3377597.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHYZU010000011
EMBL· GenBank· DDBJ
ECB8845699.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKIXE010000008
EMBL· GenBank· DDBJ
ECS2229212.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKLKV010000027
EMBL· GenBank· DDBJ
ECT0134079.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKMFT010000014
EMBL· GenBank· DDBJ
ECT2690641.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKNWZ010000003
EMBL· GenBank· DDBJ
ECT7927562.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKQHC010000018
EMBL· GenBank· DDBJ
ECU5452577.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKSPP010000021
EMBL· GenBank· DDBJ
ECV1597695.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKSBI010000027
EMBL· GenBank· DDBJ
ECV3390342.1
EMBL· GenBank· DDBJ
Genomic DNA
DAATIJ010000005
EMBL· GenBank· DDBJ
HAE8737455.1
EMBL· GenBank· DDBJ
Genomic DNA
RVCL01000007
EMBL· GenBank· DDBJ
MLO05595.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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