A0A5G2QPP1 · A0A5G2QPP1_PIG
- ProteinC-reactive protein
- GeneCRP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids259 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | calcium ion binding | |
Molecular Function | complement component C1q complex binding | |
Molecular Function | identical protein binding | |
Molecular Function | low-density lipoprotein particle binding | |
Molecular Function | low-density lipoprotein particle receptor binding | |
Biological Process | acute-phase response | |
Biological Process | negative regulation of lipid storage | |
Biological Process | negative regulation of macrophage derived foam cell differentiation | |
Biological Process | negative regulation of mononuclear cell proliferation | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of superoxide anion generation | |
Biological Process | regulation of interleukin-8 production | |
Biological Process | vasoconstriction |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameC-reactive protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionA0A5G2QPP1
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MEKLSLCLLVIISLSNAFA | ||||||
Chain | PRO_5023894797 | 20-259 | C-reactive protein | |||
Sequence: QTDLSAAMKSRNDFQPFLKREKRERPLFGLSSIFFSGVQDMIGKAFVFPKESENSYVSLTARLTKPLTAFTVCLRVYTDLNRDYSLFSYATKTQYNEILLFRGKTAVYSISVGGADVIFKPHQSSEPMHFCMTWESTSGITELWVDGKPMVRRSLKRGYSLGTQASIILGQEQDAFAGGFEKNQCLVGDIGDVNMWDYVLSPEEINTVYAGGTFSPNVLNWRALRYEMSGEVYVKPQLWP |
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length259
- Mass (Da)29,225
- Last updated2019-12-11 v1
- ChecksumD3158B7B7E98DAD9
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A287A830 | A0A287A830_PIG | CRP | 200 | ||
A0A4X1VQN0 | A0A4X1VQN0_PIG | CRP | 222 |
Keywords
- Technical term