A0A5G2QNM9 · A0A5G2QNM9_PIG

  • Protein
    Acyl-protein thioesterase 1
  • Gene
    LYPLA1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentnuclear membrane
Cellular Componentnucleoplasm
Cellular Componentplasma membrane
Molecular Functioncarboxylic ester hydrolase activity
Molecular Functionlysophospholipase activity
Molecular Functionpalmitoyl-(protein) hydrolase activity
Biological Processfatty acid transport
Biological Processnegative regulation of aggrephagy
Biological Processnegative regulation of Golgi to plasma membrane protein transport
Biological Processprotein depalmitoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acyl-protein thioesterase 1
  • EC number
  • Alternative names
    • Lysophospholipase 1
    • Lysophospholipase I
    • Palmitoyl-protein hydrolase

Gene names

    • Name
      LYPLA1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Duroc
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    A0A5G2QNM9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-61Disordered
Domain108-298Phospholipase/carboxylesterase/thioesterase

Sequence similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    303
  • Mass (Da)
    32,408
  • Last updated
    2019-12-11 v1
  • Checksum
    33CDFBCD220286E5
MRARGPRGQPGPPGAGWPDIVTRAAGGADGEARARGPGGRRGGGAHAPERAPVRGSDSPFARPWAAAGSRSAFRFRRAVCRAGVCAAITCRRLCPPSCPPPGRPPPRHGWAEAFAGIRSAHIKYICPHAPVMPVTLNMNMAMPSWFNIIGLSPDSLEDETGIKQAAENVKSLIEQEVKNGIPSNRIILGGFSQGGALSLYTALTTHQKLAGVTALSCWLPLRSSFPECPISGVNRDIPILQCHGVLDPLVPLMFGSLTVERLKTLVNPANVTFKTYEGMMHSSCQQEMLDVKQFIEKLLPPID

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1RSG9F1RSG9_PIGLYPLA1230
A0A5G2RCG0A0A5G2RCG0_PIGLYPLA1293
A0A287A534A0A287A534_PIGLYPLA1196

Keywords

Genome annotation databases

Similar Proteins

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