A0A5F9ZHJ1 · A0A5F9ZHJ1_HUMAN

  • Protein
    Adenosine kinase
  • Gene
    ADK
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 3 Mg2+ ions per subunit.

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site225Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Molecular Functionadenosine kinase activity
Molecular FunctionATP binding
Biological ProcessAMP salvage
Biological Processphosphorylation
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosine kinase
  • EC number
  • Short names
    AK
  • Alternative names
    • Adenosine 5'-phosphotransferase

Gene names

    • Name
      ADK

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A5F9ZHJ1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 216 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-264Carbohydrate kinase PfkB

Sequence similarities

Belongs to the carbohydrate kinase PfkB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    270
  • Mass (Da)
    30,167
  • Last updated
    2019-12-11 v1
  • Checksum
    50BEFE2973A11254
MIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P55263ADK_HUMANADK362
A0A5F9ZH31A0A5F9ZH31_HUMANADK294
A0A5F9ZH72A0A5F9ZH72_HUMANADK229
A0A5F9ZH76A0A5F9ZH76_HUMANADK37
A0A5F9ZH83A0A5F9ZH83_HUMANADK99
A0A5F9ZGZ8A0A5F9ZGZ8_HUMANADK179
A0A5K1VW94A0A5K1VW94_HUMANADK356
A0A5K1VW54A0A5K1VW54_HUMANADK347

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC012046
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC022026
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC022540
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC091699
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL357037
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL731576
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF455259
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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