A0A5F9ZHJ1 · A0A5F9ZHJ1_HUMAN
- ProteinAdenosine kinase
- GeneADK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids270 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Catalytic activity
- adenosine + ATP = AMP + ADP + H+
Cofactor
Note: Binds 3 Mg2+ ions per subunit.
Pathway
Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 225 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Molecular Function | adenosine kinase activity | |
Molecular Function | ATP binding | |
Biological Process | AMP salvage | |
Biological Process | phosphorylation | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosine kinase
- EC number
- Short namesAK
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A5F9ZHJ1
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 216 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-264 | Carbohydrate kinase PfkB | ||||
Sequence: HKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFP |
Sequence similarities
Belongs to the carbohydrate kinase PfkB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length270
- Mass (Da)30,167
- Last updated2019-12-11 v1
- Checksum50BEFE2973A11254
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P55263 | ADK_HUMAN | ADK | 362 | ||
A0A5F9ZH31 | A0A5F9ZH31_HUMAN | ADK | 294 | ||
A0A5F9ZH72 | A0A5F9ZH72_HUMAN | ADK | 229 | ||
A0A5F9ZH76 | A0A5F9ZH76_HUMAN | ADK | 37 | ||
A0A5F9ZH83 | A0A5F9ZH83_HUMAN | ADK | 99 | ||
A0A5F9ZGZ8 | A0A5F9ZGZ8_HUMAN | ADK | 179 | ||
A0A5K1VW94 | A0A5K1VW94_HUMAN | ADK | 356 | ||
A0A5K1VW54 | A0A5K1VW54_HUMAN | ADK | 347 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC012046 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC022026 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC022540 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC091699 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL357037 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL731576 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF455259 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |