A0A5F9ZHE0 · A0A5F9ZHE0_HUMAN
- ProteinPhosphotransferase
- GeneGCK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids486 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- ATP + D-glucose = ADP + D-glucose 6-phosphate + H+This reaction proceeds in the forward direction.
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.
Carbohydrate metabolism; hexose metabolism.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | D-glucose binding | |
Molecular Function | glucokinase activity | |
Biological Process | glycolytic process | |
Biological Process | hexose metabolic process | |
Biological Process | intracellular glucose homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphotransferase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A5F9ZHE0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
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The viewer provides 611 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 13-40 | |||||
Sequence: KEKVEQILAEFQLQEEDLKKVMRRMQKE | ||||||
Domain | 16-215 | Hexokinase N-terminal | ||||
Sequence: VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYY | ||||||
Domain | 222-287 | Hexokinase C-terminal | ||||
Sequence: VGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGDR | ||||||
Domain | 309-476 | Hexokinase C-terminal | ||||
Sequence: KYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAV |
Sequence similarities
Belongs to the hexokinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length486
- Mass (Da)54,386
- Last updated2019-12-11 v1
- ChecksumCCC0D74620A62C27
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P35557 | HXK4_HUMAN | GCK | 465 | ||
C9JQD1 | C9JQD1_HUMAN | GCK | 448 | ||
A0A8C8KJG0 | A0A8C8KJG0_HUMAN | GCK | 42 | ||
A0A5F9ZGW4 | A0A5F9ZGW4_HUMAN | GCK | 456 | ||
H7BXV0 | H7BXV0_HUMAN | GCK | 143 | ||
A0A8C8PZE6 | A0A8C8PZE6_HUMAN | GCK | 289 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC006454 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF458452 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |