A0A5F9DEH6 · A0A5F9DEH6_RABIT
- ProteinCarbonyl reductase [NADPH] 1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids378 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue.
Catalytic activity
- S-nitrosoglutathione + NADPH + H+ = S-(hydroxysulfenamide)glutathione + NADP+
- menadione + NADPH + H+ = menadiol + NADP+
- prostaglandin E2 + NADP+ = 15-oxoprostaglandin E2 + NADPH + H+This reaction proceeds in the forward direction.
- prostaglandin F2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+This reaction proceeds in the forward direction.
- corticosterone + NADPH + H+ = 20beta-dihydrocorticosterone + NADP+This reaction proceeds in the forward direction.
- cortisol + NADPH + H+ = 20beta-dihydrocortisol + NADP+This reaction proceeds in the forward direction.
- daunorubicin + NADPH + H+ = 13-dihydrodaunorubicin + NADP+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbonyl reductase (NADPH) activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarbonyl reductase [NADPH] 1
- EC number
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus
Accessions
- Primary accessionA0A5F9DEH6
Proteomes
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length378
- Mass (Da)41,269
- Last updated2019-12-11 v1
- Checksum0DFC8D067D887056
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G1TQC4 | G1TQC4_RABIT | 277 | |||
A0A5F9DGL1 | A0A5F9DGL1_RABIT | 313 | |||
A0A5F9DLZ0 | A0A5F9DLZ0_RABIT | 313 | |||
G1TIW6 | G1TIW6_RABIT | 378 | |||
G1TXK8 | G1TXK8_RABIT | 313 | |||
A0A5F9D1I1 | A0A5F9D1I1_RABIT | 313 | |||
G1SSH6 | G1SSH6_RABIT | 310 | |||
A0A5F9CQW4 | A0A5F9CQW4_RABIT | 313 |
Keywords
- Technical term