A0A5F9DEH6 · A0A5F9DEH6_RABIT

Function

function

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue.

Catalytic activity

  • S-nitrosoglutathione + NADPH + H+ = S-(hydroxysulfenamide)glutathione + NADP+
  • menadione + NADPH + H+ = menadiol + NADP+
  • prostaglandin D2 + NADP+ = 15-oxoprostaglandin D2 + NADPH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.196 (UniProtKB | ENZYME | Rhea)
  • prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + NADPH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.197 (UniProtKB | ENZYME | Rhea)
  • prostaglandin E2 + NADP+ = 15-oxoprostaglandin E2 + NADPH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin F2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin F2alpha + NADP+ = prostaglandin E2 + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.1.1.189 (UniProtKB | ENZYME | Rhea)
  • a primary alcohol + NADP+ = an aldehyde + NADPH + H+
    EC:1.1.1.71 (UniProtKB | ENZYME | Rhea)
  • a secondary alcohol + NADP+ = a ketone + NADPH + H+
    EC:1.1.1.184 (UniProtKB | ENZYME | Rhea)
  • corticosterone + NADPH + H+ = 20beta-dihydrocorticosterone + NADP+
    This reaction proceeds in the forward direction.
  • cortisol + NADPH + H+ = 20beta-dihydrocortisol + NADP+
    This reaction proceeds in the forward direction.
  • daunorubicin + NADPH + H+ = 13-dihydrodaunorubicin + NADP+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbonyl reductase (NADPH) activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbonyl reductase [NADPH] 1
  • EC number
  • Alternative names
    • 15-hydroxyprostaglandin dehydrogenase [NADP(+)]
    • 20-beta-hydroxysteroid dehydrogenase
    • Alcohol dehydrogenase [NAD(P)+] CBR1
    • Prostaglandin 9-ketoreductase
    • Prostaglandin-E(2) 9-reductase

Organism names

  • Taxonomic identifier
  • Strain
    • Thorbecke
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    A0A5F9DEH6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    378
  • Mass (Da)
    41,269
  • Last updated
    2019-12-11 v1
  • Checksum
    0DFC8D067D887056
MGIKVSSDPQHSQSEWFFVPGTQALAATNLVLSQLFCNLEAGCSNPRPALYPRNLLEHKPCTGWVRGSASLWTCSALHLDSRPTPTALLPSSGSESNSHSAMSSCSRVALVTGANKGIGYTIVRDLCRLFSGDVVLTARDEARGRVAVQQLQAEGLSPRFHQLDITDLQSIRALRDFLRKEYGGLDVLVNNAGIAFQAADITPFHIQAEVTMKTNFDGTRDVCTELLPLMRPGGRVVNVSSMESLRALKSCSPELQQKFRSETITEEELVGLMKKFVEDTKKGVHQKEGWPSTAYGVTKIGVTVLSRIQARHLSEQRGGDKILLNACCPGWVRTDMAGPNATKSPEEGAETPVYLALLPPDAEGPHGQFVVEKRVEQW

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
G1TQC4G1TQC4_RABIT277
A0A5F9DGL1A0A5F9DGL1_RABIT313
A0A5F9DLZ0A0A5F9DLZ0_RABIT313
G1TIW6G1TIW6_RABIT378
G1TXK8G1TXK8_RABIT313
A0A5F9D1I1A0A5F9D1I1_RABIT313
G1SSH6G1SSH6_RABIT310
A0A5F9CQW4A0A5F9CQW4_RABIT313

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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