A0A5F9D7N3 · A0A5F9D7N3_RABIT

Function

function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

Features

Showing features for dna binding.

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TypeIDPosition(s)Description
DNA binding400-459Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    POU domain protein

Gene names

    • Name
      POU2F2

Organism names

  • Taxonomic identifier
  • Strain
    • Thorbecke
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    A0A5F9D7N3

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_502393241821-704POU domain protein

Expression

Gene expression databases

Interaction

Subunit

Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity. Interacts with NR3C1, AR, PGR and HCFC1.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region84-111Disordered
Compositional bias96-110Pro residues
Compositional bias170-189Polar residues
Region170-210Disordered
Compositional bias190-204Pro residues
Region279-301Disordered
Domain298-372POU-specific
Region378-401Disordered
Domain398-458Homeobox
Region460-566Disordered
Compositional bias487-515Polar residues
Compositional bias534-548Pro residues
Compositional bias549-566Polar residues
Compositional bias664-688Polar residues
Region664-704Disordered

Sequence similarities

Belongs to the POU transcription factor family. Class-2 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    704
  • Mass (Da)
    72,245
  • Last updated
    2019-12-11 v1
  • Checksum
    5DFD5893D4F594D0
MWSLLGVWMRVMWLMRTLRPEEWSEATGQSVQGHEPQSQLCPPVHSCASLRLPLPHVCPLFGSQVGILSGLHLTFWGPGPCLSPPQIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGLTALMPAQQQLLLQQAQAQLLAAAVQQSNAAAAANAAAAAAASSTSSSSASSASSSTSQPPASSGGGDLPPPQPASQPPGTPQLTLSQPIQLTAQDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQGQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPHLVTPQGGAGTMPLSQASTSLSTTVTTLSSAVGTLHPSRTAGGSGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGSTMVGLSSGLNPALMSNNPLATIQALASGGTLPLTSLDGSGNLVLGAAGAAPGSPGLVTSPLFLNHAGLPLLSAPPGVGLVSAAAAAVAASISSKSPGLSSSSSSSSSSSSTCSEAAAQTPGGPGGPEAGSKSE

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F9CIN3A0A5F9CIN3_RABITPOU2F2609
A0A5F9CYI8A0A5F9CYI8_RABITPOU2F2613
G1U489G1U489_RABITPOU2F2441
A0A5F9DVC6A0A5F9DVC6_RABITPOU2F2620

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias96-110Pro residues
Compositional bias170-189Polar residues
Compositional bias190-204Pro residues
Compositional bias487-515Polar residues
Compositional bias534-548Pro residues
Compositional bias549-566Polar residues
Compositional bias664-688Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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