A0A5F9CQB8 · A0A5F9CQB8_RABIT

Function

function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Hormone biosynthesis; thyroid hormone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site483Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionheme binding
Molecular Functioniodide peroxidase activity
Biological Processhormone biosynthetic process
Biological Processhydrogen peroxide catabolic process
Biological Processresponse to oxidative stress
Biological Processthyroid hormone generation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thyroid peroxidase
  • EC number

Gene names

    • Name
      TPO

Organism names

  • Taxonomic identifier
  • Strain
    • Thorbecke
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    A0A5F9CQB8

Proteomes

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane835-858Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with DUOX1, DUOX2 and CYBA.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain728-784Sushi
Domain784-827EGF-like

Sequence similarities

Belongs to the prostaglandin G/H synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    861
  • Mass (Da)
    95,146
  • Last updated
    2019-12-11 v1
  • MD5 Checksum
    E1F7AB26A9E6E0926B601C80E9868252
MEHSAGRGFPASSTPVLTTAFLHLPPSCWLGHPHLGRIPERHYCQEAQDRGGISLMNIYILCHRNLKKRDVTSPAQLLSLSKLPEPTSRAVSRAAEIMEASNSRLLSWFSDVLSEELLGTIANLSGCLPHMLPPKCPNTCLADKYRLITGACNNRYDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLHHGFPLPAVREVTRQVIRAPNEAVTDDEQHSDFLTAWGQYISHDIAFTPQSPSRASFWGGADCQLTCENQSPCFPIQLPGNASPTACLPFYRSSPACGTGDQGALFGNLSQANPRQQMNGLTSFLDASTVYGSSPASEKQLRNWTSAEGLLRVNTRHRDAGRAYLPFAQHVPAACVPEPGAPGEPHAPCFLAGDGRASEVPSLTAVHTLWVREHNRLAAKFKALNPHWSADTTYQEARKVVGRPIITLRDYVPRILGPQAFQQHVGPYRGYDPTVNPTVSNVFSTAAFRFGHSTVHPRVRRLDAHFQEPLGLPRLQLRDVFFSPWRLIKEGGVDPLVRGLLARPAKLQAHDQLMNEELTERLFVLSNSGTLDLASLNLQRGRDHGLPGYNAWRAFCGLPRLETPAHLSEVLADRGVVHRLMDLYGHPDNIDIWLGGLAEKLLPGARTGPLFACIIGRQMKALRDGDRFWWEHGPVFTEAQRLELEKHSLSRVVCDNTGLTRVPGDAFQGGQFPQDFESCEDIPGMNLDAWRETLPQDRCGLPDPVDGGDFVLCEEAGRRRLVFSCRHGYELQGPEQVTCTPEGWDSRPPACKDVDECADPAYAPCHPSARCRNTKGSFRCTCTDPYVLGDDGRTCVDSGRLPRASWVSIALGALLVGGMAVLTWTVICRW

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
G1TBL2G1TBL2_RABITTPO883
A0A5F9CIA9A0A5F9CIA9_RABITTPO659
A0A5F9C5W2A0A5F9C5W2_RABITTPO642
A0A5F9C782A0A5F9C782_RABITTPO839
A0A5F9CZY6A0A5F9CZY6_RABITTPO185

Keywords

Genome annotation databases

Similar Proteins

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