A0A5F9CQB8 · A0A5F9CQB8_RABIT
- ProteinThyroid peroxidase
- GeneTPO
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids861 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.
Catalytic activity
- 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O
Cofactor
Pathway
Hormone biosynthesis; thyroid hormone biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 483 | Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | heme binding | |
Molecular Function | iodide peroxidase activity | |
Biological Process | hormone biosynthetic process | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | response to oxidative stress | |
Biological Process | thyroid hormone generation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThyroid peroxidase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus
Accessions
- Primary accessionA0A5F9CQB8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 835-858 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Interacts with DUOX1, DUOX2 and CYBA.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 728-784 | Sushi | |||
Domain | 784-827 | EGF-like | |||
Sequence similarities
Belongs to the prostaglandin G/H synthase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length861
- Mass (Da)95,146
- Last updated2019-12-11 v1
- MD5 ChecksumE1F7AB26A9E6E0926B601C80E9868252
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G1TBL2 | G1TBL2_RABIT | TPO | 883 | ||
A0A5F9CIA9 | A0A5F9CIA9_RABIT | TPO | 659 | ||
A0A5F9C5W2 | A0A5F9C5W2_RABIT | TPO | 642 | ||
A0A5F9C782 | A0A5F9C782_RABIT | TPO | 839 | ||
A0A5F9CZY6 | A0A5F9CZY6_RABIT | TPO | 185 |
Keywords
- Technical term