A0A5F8MPT8 · A0A5F8MPT8_MOUSE

  • Protein
    Pro-neuregulin-1, membrane-bound isoform
  • Gene
    Nrg1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular Functionsignaling receptor binding
Biological Processnervous system development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pro-neuregulin-1, membrane-bound isoform

Gene names

    • Name
      Nrg1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A0A5F8MPT8

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane76-99Helical
Transmembrane298-320Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond267↔276

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-46Disordered
Compositional bias13-27Polar residues
Region165-227Disordered
Compositional bias183-197Pro residues
Compositional bias200-227Polar residues
Domain233-277EGF-like
Region390-414Disordered
Region430-456Disordered
Region483-513Disordered
Region581-643Disordered

Sequence similarities

Belongs to the neuregulin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    695
  • Mass (Da)
    75,727
  • Last updated
    2019-12-11 v1
  • Checksum
    1CF1810BFFDF1C06
MEIYPPDMSEGAGGRSSSPSTQLSADPSLDGLPAAEHMPDTHTEDGRSPGLLGLAVPCCVCLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQDPVISLDPTAASAVLVSSEAYTSPVSKAQSEAEAHVTGQGDHVAVASEPSAVPTRKNRLSAFPPLHSTPPPFPSPARTPEVRTPKSGTQPQTTETNLQTAPKLSTSTSTTGTSHLIKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQTQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRQKLHDRLRQSLRSERNNMVNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESIISESHSVIMMSSVENSRHSSPAGGPRGRLHGLGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSVAVSPFVEEERPLLLVTPPRLREKKYDHHPQQLNSFHHNPAHQSTSLPPSPLRIVEDEEYETTQEYEPIQEPIKKVTNSRRAKRTKPNGHIANRLEMDSNPSSVSSNSESETEDERVGEDTPFLGIQNPLAASLEVAPAFRLAESRTNPAGRFSTQEELQARLSSVIANQDPIAV

Computationally mapped potential isoform sequences

There are 26 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q6DR98NRG1_MOUSENrg1645
Q6DR99Q6DR99_MOUSENrg1700
A0A5F8MP73A0A5F8MP73_MOUSENrg1433
A0A5F8MPJ0A0A5F8MPJ0_MOUSENrg1603
A0A5F8MPA3A0A5F8MPA3_MOUSENrg1604
A0A5F8MPD1A0A5F8MPD1_MOUSENrg1206
A0A5F8MPS5A0A5F8MPS5_MOUSENrg1420
A0A5F8MPT0A0A5F8MPT0_MOUSENrg1296
A0A5F8MPU1A0A5F8MPU1_MOUSENrg1485
A0A5F8MPU8A0A5F8MPU8_MOUSENrg161
A0A5F8MQ49A0A5F8MQ49_MOUSENrg1285
A0A5F8MPL7A0A5F8MPL7_MOUSENrg1324
A0A5F8MPM6A0A5F8MPM6_MOUSENrg1302
A0A5F8MPN0A0A5F8MPN0_MOUSENrg1241
A0A5F8MQ03A0A5F8MQ03_MOUSENrg1247
A0A140LJC1A0A140LJC1_MOUSENrg1640
A0A140LJ88A0A140LJ88_MOUSENrg1663
A0A140LIJ3A0A140LIJ3_MOUSENrg1472
A0A140LIK5A0A140LIK5_MOUSENrg1462
A0A140LIP8A0A140LIP8_MOUSENrg1637
A0A140LIG9A0A140LIG9_MOUSENrg1483
A0A140LHZ9A0A140LHZ9_MOUSENrg1858
A0A140LHQ6A0A140LHQ6_MOUSENrg1135
A0A140LHN1A0A140LHN1_MOUSENrg1423
A0A140LHD8A0A140LHD8_MOUSENrg1300
A0A140LHG5A0A140LHG5_MOUSENrg1459

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias13-27Polar residues
Compositional bias183-197Pro residues
Compositional bias200-227Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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