A0A5F8MPT8 · A0A5F8MPT8_MOUSE
- ProteinPro-neuregulin-1, membrane-bound isoform
- GeneNrg1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids695 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Molecular Function | signaling receptor binding | |
Biological Process | nervous system development |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended namePro-neuregulin-1, membrane-bound isoform
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A5F8MPT8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 76-99 | Helical | ||||
Sequence: ICIVPILACLVSLCLCIAGLKWVF | ||||||
Transmembrane | 298-320 | Helical | ||||
Sequence: VLTITGICIALLVVGIMCVVAYC |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 267↔276 | |||||
Sequence: CQPGFTGARC |
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-46 | Disordered | ||||
Sequence: MEIYPPDMSEGAGGRSSSPSTQLSADPSLDGLPAAEHMPDTHTEDG | ||||||
Compositional bias | 13-27 | Polar residues | ||||
Sequence: GGRSSSPSTQLSADP | ||||||
Region | 165-227 | Disordered | ||||
Sequence: ASEPSAVPTRKNRLSAFPPLHSTPPPFPSPARTPEVRTPKSGTQPQTTETNLQTAPKLSTSTS | ||||||
Compositional bias | 183-197 | Pro residues | ||||
Sequence: PLHSTPPPFPSPART | ||||||
Compositional bias | 200-227 | Polar residues | ||||
Sequence: VRTPKSGTQPQTTETNLQTAPKLSTSTS | ||||||
Domain | 233-277 | EGF-like | ||||
Sequence: HLIKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCT | ||||||
Region | 390-414 | Disordered | ||||
Sequence: SHYTSTAHHSTTVTQTPSHSWSNGH | ||||||
Region | 430-456 | Disordered | ||||
Sequence: SVENSRHSSPAGGPRGRLHGLGGPREC | ||||||
Region | 483-513 | Disordered | ||||
Sequence: MTTPARMSPVDFHTPSSPKSPPSEMSPPVSS | ||||||
Region | 581-643 | Disordered | ||||
Sequence: ETTQEYEPIQEPIKKVTNSRRAKRTKPNGHIANRLEMDSNPSSVSSNSESETEDERVGEDTPF |
Sequence similarities
Belongs to the neuregulin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length695
- Mass (Da)75,727
- Last updated2019-12-11 v1
- Checksum1CF1810BFFDF1C06
Computationally mapped potential isoform sequences
There are 26 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q6DR98 | NRG1_MOUSE | Nrg1 | 645 | ||
Q6DR99 | Q6DR99_MOUSE | Nrg1 | 700 | ||
A0A5F8MP73 | A0A5F8MP73_MOUSE | Nrg1 | 433 | ||
A0A5F8MPJ0 | A0A5F8MPJ0_MOUSE | Nrg1 | 603 | ||
A0A5F8MPA3 | A0A5F8MPA3_MOUSE | Nrg1 | 604 | ||
A0A5F8MPD1 | A0A5F8MPD1_MOUSE | Nrg1 | 206 | ||
A0A5F8MPS5 | A0A5F8MPS5_MOUSE | Nrg1 | 420 | ||
A0A5F8MPT0 | A0A5F8MPT0_MOUSE | Nrg1 | 296 | ||
A0A5F8MPU1 | A0A5F8MPU1_MOUSE | Nrg1 | 485 | ||
A0A5F8MPU8 | A0A5F8MPU8_MOUSE | Nrg1 | 61 | ||
A0A5F8MQ49 | A0A5F8MQ49_MOUSE | Nrg1 | 285 | ||
A0A5F8MPL7 | A0A5F8MPL7_MOUSE | Nrg1 | 324 | ||
A0A5F8MPM6 | A0A5F8MPM6_MOUSE | Nrg1 | 302 | ||
A0A5F8MPN0 | A0A5F8MPN0_MOUSE | Nrg1 | 241 | ||
A0A5F8MQ03 | A0A5F8MQ03_MOUSE | Nrg1 | 247 | ||
A0A140LJC1 | A0A140LJC1_MOUSE | Nrg1 | 640 | ||
A0A140LJ88 | A0A140LJ88_MOUSE | Nrg1 | 663 | ||
A0A140LIJ3 | A0A140LIJ3_MOUSE | Nrg1 | 472 | ||
A0A140LIK5 | A0A140LIK5_MOUSE | Nrg1 | 462 | ||
A0A140LIP8 | A0A140LIP8_MOUSE | Nrg1 | 637 | ||
A0A140LIG9 | A0A140LIG9_MOUSE | Nrg1 | 483 | ||
A0A140LHZ9 | A0A140LHZ9_MOUSE | Nrg1 | 858 | ||
A0A140LHQ6 | A0A140LHQ6_MOUSE | Nrg1 | 135 | ||
A0A140LHN1 | A0A140LHN1_MOUSE | Nrg1 | 423 | ||
A0A140LHD8 | A0A140LHD8_MOUSE | Nrg1 | 300 | ||
A0A140LHG5 | A0A140LHG5_MOUSE | Nrg1 | 459 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 13-27 | Polar residues | ||||
Sequence: GGRSSSPSTQLSADP | ||||||
Compositional bias | 183-197 | Pro residues | ||||
Sequence: PLHSTPPPFPSPART | ||||||
Compositional bias | 200-227 | Polar residues | ||||
Sequence: VRTPKSGTQPQTTETNLQTAPKLSTSTS |
Keywords
- Technical term