A0A5F8MPG4 · A0A5F8MPG4_MOUSE
- ProteinPhosphodiesterase
- GenePde1c
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids861 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 383 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 383-387 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNLMH | ||||||
Binding site | 387 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 423 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 424 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 424 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 424 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 531 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 531 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 582 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calmodulin binding | |
Molecular Function | calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A5F8MPG4
Proteomes
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MGSVSSVLARSRNTVVQPGSS | ||||||
Region | 1-132 | Disordered | ||||
Sequence: MGSVSSVLARSRNTVVQPGSSPPHQEVPLAAPASLKDSRTQRRVLGHQGSFRPSPAWEPPPAKHSQQELPKLESAELSPVRRRLPAMSQSSPSDSPGETGTGKTEELNTQTDATEKQPAAGEQVANEAGDKN | ||||||
Compositional bias | 84-117 | Polar residues | ||||
Sequence: LPAMSQSSPSDSPGETGTGKTEELNTQTDATEKQ | ||||||
Domain | 306-683 | PDEase | ||||
Sequence: VGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSDGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKE | ||||||
Compositional bias | 608-650 | Polar residues | ||||
Sequence: LIDESSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSDGSAPIN | ||||||
Region | 608-652 | Disordered | ||||
Sequence: LIDESSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSDGSAPINNS | ||||||
Compositional bias | 679-708 | Basic and acidic residues | ||||
Sequence: KVPKEEKAKKEAEEKARLAAEEKQKEMEAK | ||||||
Region | 679-810 | Disordered | ||||
Sequence: KVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEQGTTSKGEKKTSGEAKSQVNGTRKGDNPRGKNSKGEKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKTDGTKKRSHGSPAPSTSSTSRITLPVIKPP | ||||||
Compositional bias | 739-787 | Basic and acidic residues | ||||
Sequence: NPRGKNSKGEKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKTDGTKKR | ||||||
Compositional bias | 788-804 | Polar residues | ||||
Sequence: SHGSPAPSTSSTSRITL |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length861
- Mass (Da)96,429
- Last updated2019-12-11 v1
- Checksum39A512F8782BF2DE
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q64338 | PDE1C_MOUSE | Pde1c | 706 | ||
Q9D5W0 | Q9D5W0_MOUSE | Pde1c | 617 | ||
E9Q7V6 | E9Q7V6_MOUSE | Pde1c | 622 | ||
A0A0N4SWG4 | A0A0N4SWG4_MOUSE | Pde1c | 766 | ||
A0A0N4SW87 | A0A0N4SW87_MOUSE | Pde1c | 47 | ||
Q8CDV2 | Q8CDV2_MOUSE | Pde1c | 603 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MGSVSSVLARSRNTVVQPGSS | ||||||
Compositional bias | 84-117 | Polar residues | ||||
Sequence: LPAMSQSSPSDSPGETGTGKTEELNTQTDATEKQ | ||||||
Compositional bias | 608-650 | Polar residues | ||||
Sequence: LIDESSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSDGSAPIN | ||||||
Compositional bias | 679-708 | Basic and acidic residues | ||||
Sequence: KVPKEEKAKKEAEEKARLAAEEKQKEMEAK | ||||||
Compositional bias | 739-787 | Basic and acidic residues | ||||
Sequence: NPRGKNSKGEKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKTDGTKKR | ||||||
Compositional bias | 788-804 | Polar residues | ||||
Sequence: SHGSPAPSTSSTSRITL |
Keywords
- Technical term