A0A5F8MPG4 · A0A5F8MPG4_MOUSE

  • Protein
    Phosphodiesterase
  • Gene
    Pde1c
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site383Proton donor
Binding site383-387AMP (UniProtKB | ChEBI)
Binding site387Zn2+ 1 (UniProtKB | ChEBI)
Binding site423Zn2+ 1 (UniProtKB | ChEBI)
Binding site424AMP (UniProtKB | ChEBI)
Binding site424Zn2+ 2 (UniProtKB | ChEBI)
Binding site424Zn2+ 1 (UniProtKB | ChEBI)
Binding site531AMP (UniProtKB | ChEBI)
Binding site531Zn2+ 1 (UniProtKB | ChEBI)
Binding site582AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncalmodulin binding
Molecular Functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      Pde1c

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A0A5F8MPG4

Proteomes

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-21Polar residues
Region1-132Disordered
Compositional bias84-117Polar residues
Domain306-683PDEase
Compositional bias608-650Polar residues
Region608-652Disordered
Compositional bias679-708Basic and acidic residues
Region679-810Disordered
Compositional bias739-787Basic and acidic residues
Compositional bias788-804Polar residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    861
  • Mass (Da)
    96,429
  • Last updated
    2019-12-11 v1
  • Checksum
    39A512F8782BF2DE
MGSVSSVLARSRNTVVQPGSSPPHQEVPLAAPASLKDSRTQRRVLGHQGSFRPSPAWEPPPAKHSQQELPKLESAELSPVRRRLPAMSQSSPSDSPGETGTGKTEELNTQTDATEKQPAAGEQVANEAGDKNARPLARFSRSKSQNCLWNSLIDGLTGNIKEKPRPTIVQDTRPPEEILADELPQLDSPEALVKTSFRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSDGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEQGTTSKGEKKTSGEAKSQVNGTRKGDNPRGKNSKGEKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKTDGTKKRSHGSPAPSTSSTSRITLPVIKPPLRHFKRPAYASSSYAPSVPKKTDDHPVRYKMLDQRIKMKKIQNISHHWNKK

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q64338PDE1C_MOUSEPde1c706
Q9D5W0Q9D5W0_MOUSEPde1c617
E9Q7V6E9Q7V6_MOUSEPde1c622
A0A0N4SWG4A0A0N4SWG4_MOUSEPde1c766
A0A0N4SW87A0A0N4SW87_MOUSEPde1c47
Q8CDV2Q8CDV2_MOUSEPde1c603

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-21Polar residues
Compositional bias84-117Polar residues
Compositional bias608-650Polar residues
Compositional bias679-708Basic and acidic residues
Compositional bias739-787Basic and acidic residues
Compositional bias788-804Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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