A0A5F8HJ05 · A0A5F8HJ05_MONDO
- ProteinSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial
- GeneSDHC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids116 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.
Cofactor
Note: The heme is bound between the two transmembrane subunits.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 74 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); ligand shared with second transmembrane subunit; axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | mitochondrion | |
Molecular Function | electron transfer activity | |
Molecular Function | metal ion binding | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionA0A5F8HJ05
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 25-43 | Helical | |||
Transmembrane | 96-115 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-15 | ||||
Chain | PRO_5023848941 | 16-116 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | ||
Expression
Gene expression databases
Interaction
Subunit
Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
Structure
Sequence
- Sequence statusComplete
- Length116
- Mass (Da)12,265
- Last updated2019-12-11 v1
- Checksum44736453E7A2895F
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F7EQW5 | F7EQW5_MONDO | SDHC | 169 | ||
A0A5F8GUM6 | A0A5F8GUM6_MONDO | SDHC | 187 | ||
A0A5F8H3V8 | A0A5F8H3V8_MONDO | SDHC | 135 | ||
A0A5F8GHB6 | A0A5F8GHB6_MONDO | SDHC | 217 |
Keywords
- Technical term