A0A5F8HJ05 · A0A5F8HJ05_MONDO

Function

function

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Note: The heme is bound between the two transmembrane subunits.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site74Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); ligand shared with second transmembrane subunit; axial binding residue

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Functionelectron transfer activity
Molecular Functionmetal ion binding
Biological Processtricarboxylic acid cycle

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
  • Alternative names
    • Malate dehydrogenase [quinone] cytochrome b560 subunit

Gene names

    • Name
      SDHC

Organism names

Accessions

  • Primary accession
    A0A5F8HJ05

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane25-43Helical
Transmembrane96-115Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-15
ChainPRO_502384894116-116Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Expression

Gene expression databases

Interaction

Subunit

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    116
  • Mass (Da)
    12,265
  • Last updated
    2019-12-11 v1
  • Checksum
    44736453E7A2895F
MAALLLSWSLPMAMSICHRASGIALSAGVSLFGLAALLLPGNFESHVELLKSLSLGPALIHTAKFALVSPLMYHTWNGIRHLTWDLGMGLKIPQLYQSGVVVLALTVLSSIGLAAM

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F7EQW5F7EQW5_MONDOSDHC169
A0A5F8GUM6A0A5F8GUM6_MONDOSDHC187
A0A5F8H3V8A0A5F8H3V8_MONDOSDHC135
A0A5F8GHB6A0A5F8GHB6_MONDOSDHC217

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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