A0A5F8GWX1 · A0A5F8GWX1_MONDO
- ProteinHistidine--tRNA ligase, cytoplasmic
- GeneHARS1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids434 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.
Catalytic activity
- tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 103 | L-histidine (UniProtKB | ChEBI) | |||
Binding site | 252 | L-histidine (UniProtKB | ChEBI) | |||
Binding site | 256-257 | L-histidine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | histidine-tRNA ligase activity | |
Biological Process | tRNA aminoacylation for protein translation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidine--tRNA ligase, cytoplasmic
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionA0A5F8GWX1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length434
- Mass (Da)48,523
- Last updated2019-12-11 v1
- MD5 Checksum1AC6D0FBE068BA5E8DEC839D589C6600
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F6WHY4 | F6WHY4_MONDO | HARS1 | 508 | ||
A0A5F8GWU5 | A0A5F8GWU5_MONDO | HARS1 | 468 | ||
A0A5F8H481 | A0A5F8H481_MONDO | HARS1 | 394 |
Keywords
- Technical term