Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A5F8GWX1 · A0A5F8GWX1_MONDO

Function

function

Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.

Catalytic activity

Features

Showing features for binding site.

143450100150200250300350400
TypeIDPosition(s)Description
Binding site103L-histidine (UniProtKB | ChEBI)
Binding site252L-histidine (UniProtKB | ChEBI)
Binding site256-257L-histidine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionhistidine-tRNA ligase activity
Biological ProcesstRNA aminoacylation for protein translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidine--tRNA ligase, cytoplasmic
  • EC number
  • Alternative names
    • Histidyl-tRNA synthetase

Gene names

    • Name
      HARS1

Organism names

Accessions

  • Primary accession
    A0A5F8GWX1

Proteomes

Subcellular Location

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-59WHEP-TRS

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    434
  • Mass (Da)
    48,523
  • Last updated
    2019-12-11 v1
  • MD5 Checksum
    1AC6D0FBE068BA5E8DEC839D589C6600
MADRATLEEAVRLQGERVRGLKQQKAGAELIEEEVAKLLKLKAQLGPDEGKQKFVLKTPKGTRDYNPRQMAVREKVFDVIISCFKRHGAEVIDTPVFELKDFDIAGQFDPMIPDAECLKIICEILSALQLGDFLIKVNDRRILDGMFNVCGVPDSKFRTICSSVDKLDKMSWENVKNEMVEEKGLASEVADHIGAYVKQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIAEKISFDLSLARGLDYYTGVIYEAVLLQSPTQQGEEALGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRMEASEEKVRTTETQVLVAAAQKKLLEERLKLVAELWDRGIKAELLYKKNPKLLTQLQYCEETGIPLVAIIGEQELKDGVIKLRCVASREEVDVRKENLVEEIRKRTSQYCIC

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F6WHY4F6WHY4_MONDOHARS1508
A0A5F8GWU5A0A5F8GWU5_MONDOHARS1468
A0A5F8H481A0A5F8H481_MONDOHARS1394

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help