A0A5F8GJ40 · A0A5F8GJ40_MONDO
- ProteinMitogen-activated protein kinase kinase kinase 7
- GeneMAP3K7
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids607 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Activity regulation
Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | MAP kinase kinase kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | apoptotic process | |
Biological Process | I-kappaB phosphorylation | |
Biological Process | immune response | |
Biological Process | JNK cascade | |
Biological Process | positive regulation of JUN kinase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase 7
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionA0A5F8GJ40
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-291 | Protein kinase | ||||
Sequence: IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMQYF | ||||||
Region | 301-337 | Disordered | ||||
Sequence: PCQYSDEGQSNSATSTGSFMDITSTNTSNKSDTNMEQ | ||||||
Compositional bias | 303-337 | Polar residues | ||||
Sequence: QYSDEGQSNSATSTGSFMDITSTNTSNKSDTNMEQ | ||||||
Compositional bias | 354-382 | Polar residues | ||||
Sequence: KNQAKQQSDSGRLSLGASRGSSVESLPPS | ||||||
Region | 354-391 | Disordered | ||||
Sequence: KNQAKQQSDSGRLSLGASRGSSVESLPPSSEGKRMSAD | ||||||
Region | 444-495 | Disordered | ||||
Sequence: LSVTGTEPSQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDN | ||||||
Coiled coil | 534-565 | |||||
Sequence: YMKVQTEIALLLQRKQELVAELDQDEKDQQNT |
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length607
- Mass (Da)67,282
- Last updated2019-12-11 v1
- Checksum9D8EF0746D9C8D13
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F8G5G8 | A0A5F8G5G8_MONDO | MAP3K7 | 580 | ||
F7CCD5 | F7CCD5_MONDO | MAP3K7 | 528 | ||
A0A5F8HJG3 | A0A5F8HJG3_MONDO | MAP3K7 | 518 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 303-337 | Polar residues | ||||
Sequence: QYSDEGQSNSATSTGSFMDITSTNTSNKSDTNMEQ | ||||||
Compositional bias | 354-382 | Polar residues | ||||
Sequence: KNQAKQQSDSGRLSLGASRGSSVESLPPS |
Keywords
- Technical term