A0A5F8GJ40 · A0A5F8GJ40_MONDO

Function

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site63ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular FunctionMAP kinase kinase kinase activity
Molecular Functionprotein serine kinase activity
Biological Processapoptotic process
Biological ProcessI-kappaB phosphorylation
Biological Processimmune response
Biological ProcessJNK cascade
Biological Processpositive regulation of JUN kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase kinase kinase 7
  • EC number

Gene names

    • Name
      MAP3K7

Organism names

Accessions

  • Primary accession
    A0A5F8GJ40

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain36-291Protein kinase
Region301-337Disordered
Compositional bias303-337Polar residues
Compositional bias354-382Polar residues
Region354-391Disordered
Region444-495Disordered
Coiled coil534-565

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    607
  • Mass (Da)
    67,282
  • Last updated
    2019-12-11 v1
  • Checksum
    9D8EF0746D9C8D13
MSTASAASSSSSSSAGEMIETPSQVLRFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMQYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDITSTNTSNKSDTNMEQIPATNDTIKRLESKLLKNQAKQQSDSGRLSLGASRGSSVESLPPSSEGKRMSADMSEIEARIAATTACSKPKRGHRKTASFGNILDVPQIVISAGNGQPRRRSIQDLSVTGTEPSQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8G5G8A0A5F8G5G8_MONDOMAP3K7580
F7CCD5F7CCD5_MONDOMAP3K7528
A0A5F8HJG3A0A5F8HJG3_MONDOMAP3K7518

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias303-337Polar residues
Compositional bias354-382Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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