A0A5F8ATQ0 · A0A5F8ATQ0_MACMU

  • Protein
    Transient receptor potential cation channel subfamily M member 7
  • Gene
    TRPM7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

123792004006008001,0001,2001,4001,6001,8002,0002,200
TypeIDPosition(s)Description
Binding site2138ATP (UniProtKB | ChEBI)
Binding site2162ATP (UniProtKB | ChEBI)
Binding site2234ATP (UniProtKB | ChEBI)
Binding site2267Zn2+ (UniProtKB | ChEBI)
Active site2281Proton acceptor
Binding site2283ATP (UniProtKB | ChEBI)
Binding site2291ATP (UniProtKB | ChEBI)
Binding site2308-2314ATP (UniProtKB | ChEBI)
Binding site2324Zn2+ (UniProtKB | ChEBI)
Binding site2326Zn2+ (UniProtKB | ChEBI)
Binding site2330Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic side of endoplasmic reticulum membrane
Cellular Componentcytoplasmic vesicle
Cellular Componentlumenal side of endoplasmic reticulum membrane
Cellular Componentplasma membrane
Cellular Componentruffle
Molecular Functionactin binding
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Molecular FunctionATP binding
Molecular Functioncalcium channel activity
Molecular Functionmetal ion binding
Molecular Functionmyosin binding
Molecular Functionprotein serine/threonine kinase activity
Biological Processactomyosin structure organization
Biological Processcalcium ion transport
Biological Processcalcium-dependent cell-matrix adhesion
Biological Processintracellular magnesium ion homeostasis
Biological Processmonoatomic cation homeostasis
Biological Processmonoatomic cation transmembrane transport
Biological Processnecroptotic process
Biological Processprotein phosphorylation
Biological Processprotein tetramerization
Biological Processzinc ion transport

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Transient receptor potential cation channel subfamily M member 7

Gene names

    • Name
      TRPM7

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    A0A5F8ATQ0

Proteomes

Organism-specific databases

Subcellular Location

Endomembrane system
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane170-189Helical
Transmembrane215-240Helical
Transmembrane246-268Helical
Transmembrane289-306Helical
Transmembrane341-361Helical
Transmembrane410-440Helical
Transmembrane452-476Helical
Transmembrane482-499Helical
Transmembrane1270-1287Helical
Transmembrane1369-1389Helical
Transmembrane1436-1458Helical
Transmembrane1470-1489Helical
Transmembrane1510-1529Helical
Transmembrane1591-1614Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_502380824826-2379

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1057-1075Polar residues
Region1057-1087Disordered
Domain2108-2338Alpha-type protein kinase
Region2350-2379Disordered
Compositional bias2357-2379Polar residues

Sequence similarities

Belongs to the peptidase A22B family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,379
  • Mass (Da)
    269,749
  • Last updated
    2019-12-11 v1
  • Checksum
    0935C3345280E7C5
MGPQRQLSPAGAALLWGFLLPLTAAQEAILHASGNGTTKDYCMLYNPYWTTLPSTLENATSVSLMDLTSTPLCNLSDVPSVGIKSKAVVVPWGSCQFFEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISHKDFKDANQILGNNITVKMYSPSWPDFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEDYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKSMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKNDGNLVEATGQPSAPHEKLPVVIRVPKLIYLSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASIVAWRRKEMKKFWKGNSYQSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEAVHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVVEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQIKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDGPVRPSVWKKHSIVNTLSSSVPQGDLESNNPFLCNILMKDDKDPQCNIFGQDLPAIPQRKEFNFPEAGSSSGALFASAGSPPELRQRLHGVELLKIFNKNQKLGSSSNSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKAAEGDNIEFGAFVGHRDSMDLQRFKETSNKIKEILFNNNTSEKTLKRVSSLAGFTDCHRTSIPLHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNSVRLML

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8AAE9A0A5F8AAE9_MACMUTRPM71866
F6UIC3F6UIC3_MACMUTRPM71865
A0A5F7ZZG9A0A5F7ZZG9_MACMUTRPM71829
A0A5F7ZQX0A0A5F7ZQX0_MACMUTRPM71993
F6ZE09F6ZE09_MACMUTRPM72361
A0A1D5QLT0A0A1D5QLT0_MACMUTRPM7538
A0A5F8AQF5A0A5F8AQF5_MACMUTRPM71823

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1057-1075Polar residues
Compositional bias2357-2379Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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