A0A5F8ATQ0 · A0A5F8ATQ0_MACMU
- ProteinTransient receptor potential cation channel subfamily M member 7
- GeneTRPM7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2379 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 2138 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 2162 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2234 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2267 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 2281 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 2283 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 2291 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2308-2314 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GPANLGE | ||||||
Binding site | 2324 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2326 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2330 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A5F8ATQ0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endomembrane system ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 170-189 | Helical | ||||
Sequence: YTMVVIFVIAVFTVALGGYW | ||||||
Transmembrane | 215-240 | Helical | ||||
Sequence: YLTFSPLTVVIFVVICCVMMVLLYFF | ||||||
Transmembrane | 246-268 | Helical | ||||
Sequence: YVMIAIFCIASAMSLYNCLAALI | ||||||
Transmembrane | 289-306 | Helical | ||||
Sequence: LIFLSGLCIAVAVVWAVF | ||||||
Transmembrane | 341-361 | Helical | ||||
Sequence: VILLGLLLLYDVFFVFITPFI | ||||||
Transmembrane | 410-440 | Helical | ||||
Sequence: LIYLSVMSVCLMPVSILGFGDIIVPGLLIAY | ||||||
Transmembrane | 452-476 | Helical | ||||
Sequence: YIYYVSSTVAYAIGMILTFVVLVLM | ||||||
Transmembrane | 482-499 | Helical | ||||
Sequence: ALLYLVPCTLITASIVAW | ||||||
Transmembrane | 1270-1287 | Helical | ||||
Sequence: SWYKVILSILVPPAILLL | ||||||
Transmembrane | 1369-1389 | Helical | ||||
Sequence: FWFNTLAYLGFLMLYTFVVLV | ||||||
Transmembrane | 1436-1458 | Helical | ||||
Sequence: YFNISDTIAIISFFIGFGLRFGA | ||||||
Transmembrane | 1470-1489 | Helical | ||||
Sequence: VFVAGRLIYCLNIIFWYVRL | ||||||
Transmembrane | 1510-1529 | Helical | ||||
Sequence: VANMFYIVVIMALVLLSFGV | ||||||
Transmembrane | 1591-1614 | Helical | ||||
Sequence: AVYLFVQYIIMVNLLIAFFNNVYL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MGPQRQLSPAGAALLWGFLLPLTAA | ||||||
Chain | PRO_5023808248 | 26-2379 | ||||
Sequence: QEAILHASGNGTTKDYCMLYNPYWTTLPSTLENATSVSLMDLTSTPLCNLSDVPSVGIKSKAVVVPWGSCQFFEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISHKDFKDANQILGNNITVKMYSPSWPDFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEDYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKSMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKNDGNLVEATGQPSAPHEKLPVVIRVPKLIYLSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASIVAWRRKEMKKFWKGNSYQSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEAVHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVVEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQIKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDGPVRPSVWKKHSIVNTLSSSVPQGDLESNNPFLCNILMKDDKDPQCNIFGQDLPAIPQRKEFNFPEAGSSSGALFASAGSPPELRQRLHGVELLKIFNKNQKLGSSSNSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKAAEGDNIEFGAFVGHRDSMDLQRFKETSNKIKEILFNNNTSEKTLKRVSSLAGFTDCHRTSIPLHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNSVRLML |
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1057-1075 | Polar residues | ||||
Sequence: NRRSGRNTSSSTPQLRKSH | ||||||
Region | 1057-1087 | Disordered | ||||
Sequence: NRRSGRNTSSSTPQLRKSHESFGNRADKKEK | ||||||
Domain | 2108-2338 | Alpha-type protein kinase | ||||
Sequence: ILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDL | ||||||
Region | 2350-2379 | Disordered | ||||
Sequence: FPQDEPSDLNLQPGNSTKESESTNSVRLML | ||||||
Compositional bias | 2357-2379 | Polar residues | ||||
Sequence: DLNLQPGNSTKESESTNSVRLML |
Sequence similarities
Belongs to the peptidase A22B family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,379
- Mass (Da)269,749
- Last updated2019-12-11 v1
- Checksum0935C3345280E7C5
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F8AAE9 | A0A5F8AAE9_MACMU | TRPM7 | 1866 | ||
F6UIC3 | F6UIC3_MACMU | TRPM7 | 1865 | ||
A0A5F7ZZG9 | A0A5F7ZZG9_MACMU | TRPM7 | 1829 | ||
A0A5F7ZQX0 | A0A5F7ZQX0_MACMU | TRPM7 | 1993 | ||
F6ZE09 | F6ZE09_MACMU | TRPM7 | 2361 | ||
A0A1D5QLT0 | A0A1D5QLT0_MACMU | TRPM7 | 538 | ||
A0A5F8AQF5 | A0A5F8AQF5_MACMU | TRPM7 | 1823 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1057-1075 | Polar residues | ||||
Sequence: NRRSGRNTSSSTPQLRKSH | ||||||
Compositional bias | 2357-2379 | Polar residues | ||||
Sequence: DLNLQPGNSTKESESTNSVRLML |
Keywords
- Technical term