A0A5F7ZZG9 · A0A5F7ZZG9_MACMU
- Proteinnon-specific serine/threonine protein kinase
- GeneTRPM7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1829 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 1588 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1612 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1684 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1717 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 1731 | Proton acceptor | |||
Binding site | 1733 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1741 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1758-1764 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1774 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 1776 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 1780 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | calcium channel activity | |
Molecular Function | histone H2AS1 kinase activity | |
Molecular Function | metal ion binding | |
Biological Process | protein phosphorylation | |
Biological Process | protein tetramerization |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A5F7ZZG9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 741-759 | Helical | |||
Transmembrane | 839-861 | Helical | |||
Transmembrane | 906-928 | Helical | |||
Transmembrane | 940-959 | Helical | |||
Transmembrane | 980-999 | Helical | |||
Transmembrane | 1061-1084 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 527-545 | Polar residues | |||
Region | 527-557 | Disordered | |||
Domain | 1558-1788 | Alpha-type protein kinase | |||
Region | 1800-1829 | Disordered | |||
Compositional bias | 1807-1829 | Polar residues | |||
Sequence similarities
In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,829
- Mass (Da)208,506
- Last updated2019-12-11 v1
- ChecksumB89ACF44EB2E1252
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F8AAE9 | A0A5F8AAE9_MACMU | TRPM7 | 1866 | ||
F6UIC3 | F6UIC3_MACMU | TRPM7 | 1865 | ||
A0A5F7ZQX0 | A0A5F7ZQX0_MACMU | TRPM7 | 1993 | ||
A0A5F8ATQ0 | A0A5F8ATQ0_MACMU | TRPM7 | 2379 | ||
F6ZE09 | F6ZE09_MACMU | TRPM7 | 2361 | ||
A0A1D5QLT0 | A0A1D5QLT0_MACMU | TRPM7 | 538 | ||
A0A5F8AQF5 | A0A5F8AQF5_MACMU | TRPM7 | 1823 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 527-545 | Polar residues | |||
Compositional bias | 1807-1829 | Polar residues | |||
Keywords
- Technical term