A0A5F7ZNG6 · A0A5F7ZNG6_MACMU
- Proteinreceptor protein-tyrosine kinase
- GeneFLT1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1300 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 834-841 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GRGAFGKV | ||||||
Binding site | 861 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Active site | 984 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 988 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 989 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 1002 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | vascular endothelial growth factor receptor activity | |
Biological Process | angiogenesis | |
Biological Process | vascular endothelial growth factor receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A5F7ZNG6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MVFCWDTGVLLCALLGCLLLTGSSSG | ||||||
Chain | PRO_5023816763 | 27-1300 | receptor protein-tyrosine kinase | |||
Sequence: SKLKGPELSLKGTQHVTQAGQTLHLQCRGEAAHQWSLPETVSKESKRLSITKSACGRNGKQFCSTLTLNAAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELIIPCRVTSPNITVTLKKFPLDTLIPDGKRVIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLILNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSILTIDKVQNKDKGLYTCRVRSGPSFKYVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPRPTIKWCWRPCNHNHSEARYDFCSNNEESFILDPDSNIGNRIESITQRMAIIEGKNKTASTLVVADSRISGIYSCIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLEDSGTYACRARNVYTGEEILQKKEVTIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKEGISAPKFNSESSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTWTDSKPKASLKIDLRVTSKSKESGLSDASRPSFCHSSCGHISEGKRRFTYDNAELERKIACCSPPPDYNSVVLYSTPPV |
Keywords
- PTM
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 32-107 | Ig-like | ||||
Sequence: PELSLKGTQHVTQAGQTLHLQCRGEAAHQWSLPETVSKESKRLSITKSACGRNGKQFCSTLTLNAAQANHTGFYSC | ||||||
Domain | 230-327 | Ig-like | ||||
Sequence: IDVQISTPRPVKLLRGHTLILNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSILTIDKVQNKDKGLYTCRVRSGPSFKYVNTSVH | ||||||
Domain | 349-404 | Ig-like | ||||
Sequence: GKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYT | ||||||
Domain | 428-553 | Ig-like | ||||
Sequence: PQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPRPTIKWCWRPCNHNHSEARYDFCSNNEESFILDPDSNIGNRIESITQRMAIIEGKNKTASTLVVADSRISGIYSCIASNKVGTVGRNISFYIT | ||||||
Domain | 556-654 | Ig-like | ||||
Sequence: PNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLEDSGTYACRARNVYTGEEILQKKEVT | ||||||
Domain | 661-747 | Ig-like | ||||
Sequence: PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLT | ||||||
Domain | 827-1120 | Protein kinase | ||||
Sequence: LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL | ||||||
Region | 902-944 | Disordered | ||||
Sequence: PKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEE | ||||||
Compositional bias | 918-936 | Polar residues | ||||
Sequence: RLDSVTSSESFASSGFQED |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,300
- Mass (Da)146,596
- Last updated2019-12-11 v1
- Checksum2A0FD87881CDF8AC
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F7FAY2 | F7FAY2_MACMU | FLT1 | 1474 | ||
A0A1D5R5Q1 | A0A1D5R5Q1_MACMU | FLT1 | 619 | ||
A0A5F8AH06 | A0A5F8AH06_MACMU | FLT1 | 1357 | ||
A0A5F7ZIZ0 | A0A5F7ZIZ0_MACMU | FLT1 | 665 | ||
A0A1D5R1D8 | A0A1D5R1D8_MACMU | FLT1 | 1258 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 918-936 | Polar residues | ||||
Sequence: RLDSVTSSESFASSGFQED |
Keywords
- Technical term