A0A5F5Y7A4 · A0A5F5Y7A4_FELCA

Function

Catalytic activity

  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.3 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H+
    This reaction proceeds in the forward direction.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site170Nucleophile
Active site194Charge relay system
Binding site208Ca2+ (UniProtKB | ChEBI)
Binding site210Ca2+ (UniProtKB | ChEBI)
Binding site213Ca2+ (UniProtKB | ChEBI)
Active site281Charge relay system

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionall-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
Molecular Functionmetal ion binding
Molecular Functiontriacylglycerol lipase activity
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Triacylglycerol lipase
  • EC number
  • Alternative names
    • Pancreatic lipase

Gene names

    • Name
      PNLIPRP1

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    A0A5F5Y7A4

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_502397125118-467Triacylglycerol lipase
Disulfide bond21↔27
Disulfide bond108↔119
Disulfide bond255↔279
Disulfide bond303↔314
Disulfide bond317↔322
Disulfide bond451↔467

Keywords

Expression

Gene expression databases

Interaction

Subunit

Forms a 1:1 stoichiometric complex with (pro)colipase/CLPS.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain356-467PLAT

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    467
  • Mass (Da)
    51,396
  • Last updated
    2019-12-11 v1
  • Checksum
    E9F5D53B74FD6DD3
MMLLIWTLSLLLGAVVGKEICFPRLGCFSDDAPWAGIAQRPLKILPWPPKDVNTRFLLYTNENPNNFEEIIADESTIMSSNFNTDRKTRFIIHGFIDKGEENWLSKICKNLFTVESVNCICVDWKSGSKTGYTQASQNIRIVGAEVAYFVEVLQSAFGYSPSNVHIIGHSLGAHAAGEAGRRINGTAGRITGLDPAEPCFEGTPDLVRLDPSDALFVDVIHTDAAPIIPNMGFGMSQTVGHLDFFPNGGKEMPGCQKNILSQIVDIDGIWEGTRDFVACNHLRSYKYYSESILNPDGFASYPCASYKAFESNKCFPCPDEGCPQMGHYADKFAGRTSGEPQKFFLNTGDSSNFARWRYGVSITLSGKIATGQVKVALFGNKGNTHQFDVIRGILTPGSTHSNQFDAKLDIGTIEKVKFLWNNNVINPTFPKVGAAKITVQKGEEKTVHNFCSESTVREDVLLTLTPC

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M3WPS6M3WPS6_FELCAPNLIPRP1467
A0A5F5XSU9A0A5F5XSU9_FELCAPNLIPRP1495
A0A5F5Y5N1A0A5F5Y5N1_FELCAPNLIPRP1467
A0A5F5Y684A0A5F5Y684_FELCAPNLIPRP1486
M3VWT0M3VWT0_FELCAPNLIPRP1469
A0A0A0MPX7A0A0A0MPX7_FELCAPNLIPRP1465

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04000273
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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