A0A5F5PHZ5 · A0A5F5PHZ5_HORSE
- ProteinLegumain
- GeneLGMN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids376 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 148 | ||||
Active site | 189 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | cysteine-type endopeptidase activity | |
Biological Process | proteolysis involved in protein catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLegumain
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus
Accessions
- Primary accessionA0A5F5PHZ5
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-17 | ||||
Chain | PRO_5023833473 | 18-376 | Legumain | ||
Expression
Gene expression databases
Interaction
Subunit
Homodimer before autocatalytic removal of the propeptide. Monomer after autocatalytic processing. May interact with integrins.
Structure
Sequence
- Sequence statusComplete
- Length376
- Mass (Da)42,692
- Last updated2019-12-11 v1
- MD5 Checksum832F6D139C8AC4C7F349A9D202B3E3A2
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F5PT09 | A0A5F5PT09_HORSE | LGMN | 433 | ||
F6QSX9 | F6QSX9_HORSE | LGMN | 444 | ||
A0A3Q2HZT8 | A0A3Q2HZT8_HORSE | LGMN | 393 | ||
A0A9L0SGG1 | A0A9L0SGG1_HORSE | LGMN | 373 |
Keywords
- Technical term