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A0A5F5PHZ5 · A0A5F5PHZ5_HORSE

Function

function

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.

Catalytic activity

  • Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.
    EC:3.4.22.34 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

137650100150200250300350
TypeIDPosition(s)Description
Active site148
Active site189Nucleophile

GO annotations

AspectTerm
Molecular Functioncysteine-type endopeptidase activity
Biological Processproteolysis involved in protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Legumain
  • EC number
  • Alternative names
    • Protease, cysteine 1

Gene names

    • Name
      LGMN

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A5F5PHZ5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_502383347318-376Legumain

Expression

Gene expression databases

Interaction

Subunit

Homodimer before autocatalytic removal of the propeptide. Monomer after autocatalytic processing. May interact with integrins.

Family & Domains

Sequence similarities

Belongs to the peptidase C13 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    376
  • Mass (Da)
    42,692
  • Last updated
    2019-12-11 v1
  • MD5 Checksum
    832F6D139C8AC4C7F349A9D202B3E3A2
MIWEVAVLLSLVLGVGALPMDDPEDGGKHWVVIVAGSNGWFNYRHQADVCHAYQIVHRNGIPDEQVIVMMYDDIAYSEENPTPGIVINRPNGSDVYAGVPKDYTGKDVNPQNFLAVLKGDSEAVKGKGSGKVLKSGPKDHVFVYFTDHGATGILCFPDDDLHVQDLNQTIYFMYQHKMYRKLVFYIEACESGSMMHHLPADINVYATTASNPSESSYACYYDDERVTYLGDWYSVNWMEDSDMEDLTKETLHKQYQLVKSHTNTSHVMQYGNKSISAMKVVEFQGVKHKASSPISLPPVKRLDLTPSPDVPLAILKRRLMSTNDLQESRHLAEDIRRHLEYEYALRHLYVLVNLCEQPYPVDRIKSSMDKVCLDNY

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F5PT09A0A5F5PT09_HORSELGMN433
F6QSX9F6QSX9_HORSELGMN444
A0A3Q2HZT8A0A3Q2HZT8_HORSELGMN393
A0A9L0SGG1A0A9L0SGG1_HORSELGMN373

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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